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Reviewed, UniProtKB/Swiss-Prot P65605 (OTCC2_STRA3)

Last modified February 9, 2010. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ornithine carbamoyltransferase 2, catabolic
      Short name=OTCase 2
    EC=2.1.3.3
Gene names
Name: arcB2
Ordered Locus Names: gbs2124
OrganismStreptococcus agalactiae serotype III [Complete proteome] [HAMAP]
Taxonomic identifier216495 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

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Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm Probable HAMAP MF_01109.

Sequence similarities

Belongs to the ATCase/OTCase family.

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Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 337337Ornithine carbamoyltransferase 2, catabolic HAMAP MF_01109
PRO_0000113027

Regions

Region57 – 615Carbamoyl phosphate binding By similarity
Region271 – 2744Ornithine binding By similarity

Sites

Binding site1081Carbamoyl phosphate By similarity
Binding site1351Carbamoyl phosphate By similarity
Site321Important for structural integrity By similarity
Site1481Important for structural integrity By similarity

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Sequences

Sequence LengthMass (Da)Tools
P65605-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 420ADF4225E1CE64

FASTA33738,119
        10         20         30         40         50         60 
MTQVFQGRSF LAEKDFSREE FEYLIDFSAH LKDLKKRGVP HHYLEGKNIA LLFEKTSTRT 

        70         80         90        100        110        120 
RAAFTTAAID LGAHPEYLGA NDIQLGKKES TEDTAKVLGR MFDGIEFRGF SQRMVEELAE 

       130        140        150        160        170        180 
FSGVPVWNGL TDEWHPTQML ADYLTIKENF GKLEGITLVY CGDGRNNVAN SLLVAGTLMG 

       190        200        210        220        230        240 
VNVHIFSPKE LFPAEEIVKL AEEYAKESGA HVLVTDNVDE AVKGADVFYT DVWVSMGEED 

       250        260        270        280        290        300 
KFKERVELLQ PYQVNMELIK KANNDNLIFL HCLPAFHDTN TVYGKDVAEK FGVKEMEVTD 

       310        320        330 
EVFRSKYARH FDQAENRMHT IKAVMAATLG NLFIPKV

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References

[1]"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease."
Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.
Mol. Microbiol. 45:1499-1513(2002) [PubMed: 12354221] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NEM316 / Serotype III.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL766856 Genomic DNA. Translation: CAD47783.1.
RefSeqNP_736554.1.

3D structure databases

SMRP65605. Positions 4-332.
ModBaseSearch...

Genome annotation databases

GeneID1031070.
KEGGsan:gbs2124.

Organism-specific databases

SagaListgbs2124.
CMRSearch...

Phylogenomic databases

HOGENOMHBG579429.
OMANHETVES.

Enzyme and pathway databases

BioCycSAGA211110:GBS2124-MONOMER.

Family and domain databases

HAMAPMF_01109. OTCase.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P_bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn_bd.
IPR002292. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
TIGRFAMsTIGR00658. orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameOTCC2_STRA3
AccessionPrimary (citable) accession number: P65605
Secondary accession number(s): Q8DWQ0, Q8E2J8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: February 9, 2010
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents