P65603 (OTCC1_STRA3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase 1, catabolic
Short name=OTCase 1
EC=2.1.3.3

Gene names

Name:	arcB1
Ordered Locus Names:	gbs2085

Organism

Streptococcus agalactiae serotype III [Complete proteome] [HAMAP]

Taxonomic identifier

216495 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Ornithine carbamoyltransferase 1, catabolic HAMAP MF_01109		PRO_0000113025
Regions
	Region	56 – 60	5	Carbamoyl phosphate binding By similarity
	Region	272 – 275	4	Ornithine binding By similarity
Sites
	Binding site	107	1	Carbamoyl phosphate By similarity
	Binding site	134	1	Carbamoyl phosphate By similarity
	Site	31	1	Important for structural integrity By similarity
	Site	147	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	P65603 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: B51A22BF6135652B	FASTA	332	37,220
	10 20 30 40 50 60 MKNLRNRSFL TLLDFSTAEV EFLLKLSEDL KRAKYAGIEQ QKLVGKNIAL IFEKDSTRTR 70 80 90 100 110 120 CAFEVAAHDQ GAHVTYLGPT GSQMGKKETS KDTARVLGGM YDGIEYRGFS QETVETLAEF 130 140 150 160 170 180 SGVPVWNGLT DADHPTQVLA DFLTAKECLH KPYKDIRFTY VGDGRNNVAN ALMIGASIVG 190 200 210 220 230 240 MTYHLVCPKE LEPDPELLSK CQEIAKTTGA SIEITADIAE GVRDSDVLYT DVWVSMGEPD 250 260 270 280 290 300 EVWKERIALL EPYRITQEML NMTENPNVIF EHCLPSFHNI DTKVGYDIYE KYGLKEMEVS 310 320 330 DEVFEGPHSV VFQEAENRMH TIKAVMVATL GD

References

[1]	"Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease." Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F. Mol. Microbiol. 45:1499-1513(2002) [PubMed: 12354221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NEM316 / Serotype III.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL766856 Genomic DNA. Translation: CAD47744.1.
RefSeq	NP_736515.1. NC_004368.1.
3D structure databases
ProteinModelPortal	P65603.
SMR	P65603. Positions 2-332.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000002577; EBSTRP00000002495; EBSTRG00000002577.
GeneID	1031013.
GenomeReviews	Gene locus gbs2085 in contig AL732656_GR.
KEGG	san:gbs2085.
PATRIC	19640107. VBIStrAga3577_2138.
Organism-specific databases
GenoList	gbs2085.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000027080.
HOGENOM	HBG579429.
OMA	MTPYQIN.
ProtClustDB	PRK04284.
Enzyme and pathway databases
BioCyc	SAGA211110:GBS2085-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC1_STRA3

Accession

Primary (citable) accession number: P65603
Secondary accession number(s): Q8DWT7, Q8E2N7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program