P65601 (OTCC_STAAM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase, catabolic
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	arcB
Ordered Locus Names:	SAV2634

Organism

Staphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]

Taxonomic identifier

158878 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Arginine metabolism
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 336	336	Ornithine carbamoyltransferase, catabolic HAMAP MF_01109		PRO_0000113011
Regions
	Region	62 – 66	5	Carbamoyl phosphate binding By similarity
	Region	276 – 279	4	Ornithine binding By similarity
Sites
	Binding site	113	1	Carbamoyl phosphate By similarity
	Binding site	140	1	Carbamoyl phosphate By similarity
	Site	37	1	Important for structural integrity By similarity
	Site	153	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	P65601 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: E86B70583F566AF4	FASTA	336	37,777
	10 20 30 40 50 60 MTEIQKPYDL KGRSLLKESD FTKAEFEGLI DFAITLKEYK KNGIKHHYLS GKNIALLFEK 70 80 90 100 110 120 NSTRTRAAFT VASIDLGAHP EFLGKNDIQL GKKESVEDTA KVLGRMFDGI EFRGFSQQAV 130 140 150 160 170 180 EDLAKFSGVP VWNGLTDDWH PTQMLADFMT IKENFGYLEG INLTYVGDGR NNIAHSLMVA 190 200 210 220 230 240 GAMLGVNVRI CTPKSLNPKE AYVDIAKEKA SQYGGSIMIT DNIAEAVENT DAIYTDVWVS 250 260 270 280 290 300 MGEESEFEQR INLLKDYQVN QQMFDLTGKD STIFLHCLPA FHDTNTLYGQ EIYEKYGLAE 310 320 330 MEVTDQIFRS EHSKVFDQAE NRMHTIKAVM AATLGS

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Mu50 / ATCC 700699.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000017 Genomic DNA. Translation: BAB58796.1.
RefSeq	NP_373158.1. NC_002758.2.
3D structure databases
ProteinModelPortal	P65601.
ModBase	Search...
Protein-protein interaction databases
STRING	P65601.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000006848; EBSTAP00000006666; EBSTAG00000006847.
GeneID	1122659.
GenomeReviews	Gene locus SAV2634 in contig BA000017_GR.
KEGG	sav:SAV2634.
PATRIC	19566208. VBIStaAur52173_2730.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
GeneTree	EBGT00050000023906.
HOGENOM	HBG579429.
OMA	VRICTPE.
ProtClustDB	PRK02102.
Enzyme and pathway databases
BioCyc	SAUR158878:SAV2634-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTCC_STAAM

Accession

Primary (citable) accession number: P65601
Secondary accession number(s): Q99R03

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program