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Reviewed, UniProtKB/Swiss-Prot P65575 (NUOB_MYCTU)

Last modified November 25, 2008. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-quinone oxidoreductase subunit B
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit B
    NDH-1 subunit B
Gene names
Name: nuoB
Ordered Locus Names: Rv3146, MT3234
ORF Names: MTCY03A2.12c
OrganismMycobacterium tuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD(+) + quinol.

Cofactor

Binds 1 4Fe-4S cluster Potential.

Sequence similarities

Belongs to the complex I 20 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 184184NADH-quinone oxidoreductase subunit B
PRO_0000118773

Sites

Metal binding371Iron-sulfur (4Fe-4S) Potential
Metal binding381Iron-sulfur (4Fe-4S) Potential
Metal binding1031Iron-sulfur (4Fe-4S) Potential
Metal binding1321Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P65575-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 9E8C05D2A8BC18A0

FASTA18420,219
        10         20         30         40         50         60 
MGLEEQLPGG ILLSTVEKVA GYVRKNSLWP ATFGLACCAI EMMATAGPRF DIARFGMERF 

        70         80         90        100        110        120 
SATPRQADLM IVAGRVSQKM APVLRQIYDQ MAEPKWVLAM GVCASSGGMF NNYAIVQGVD 

       130        140        150        160        170        180 
HVVPVDIYLP GCPPRPEMLL HAILKLHEKI QQMPLGINRE RAIAEAEEAA LLARPTIEMR 


GLLR 

« Hide

Cross-references

Sequence databases

BX842582 Genomic DNA. Translation: CAB06270.1.
AE000516 Genomic DNA. Translation: AAK47573.1.
PIRC70647.
RefSeqNP_217662.1.
NP_337759.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID888791.
923386.
GenomeReviewsGene locus MT3234 in contig AE000516_GR.
Gene locus Rv3146 in contig AL123456_GR.
KEGGmtc:MT3234.
mtu:Rv3146.
TIGRMT3234.

Organism-specific databases

TubercuListRv3146.

Phylogenomic databases

HOGENOMP65575.

Family and domain databases

InterProIPR006138. NADH_DHase_20kDa_su.
IPR014406. NiFe_hyd_3_ssu/Q_oxred_NuoB.
IPR006137. OxRdtase_q6.
[Graphical view]
PANTHERPTHR11995:SF2. NADH_DH_20kDa. 1 hit.
PTHR11995. NiFe_hyd_3_ssu/Q_oxred_NuoB. 1 hit.
PfamPF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsTIGR01957. nuoB_fam. 1 hit.
PROSITEPS01150. COMPLEX1_20K. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOB_MYCTU
AccessionPrimary (citable) accession number: P65575
Secondary accession number(s): P95180
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 25, 2008
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents