Reviewed, UniProtKB/Swiss-Prot P65572 (NUOC_MYCBO)

Names and origin

Protein names

Recommended name:
    NADH-quinone oxidoreductase subunit C
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit C
    NDH-1 subunit C

Gene names

Name:	nuoC
Ordered Locus Names:	Mb3171

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	236 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.
Catalytic activity	NADH + quinone = NAD(+) + quinol.
Sequence similarities	Belongs to the complex I 30 kDa subunit family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mitochondrial electron transport, NADH to ubiquinone Inferred from electronic annotation. Source: InterPro
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 236	236	NADH-quinone oxidoreductase subunit C		PRO_0000118671

Sequences

	Sequence		Length	Mass (Da)
	P65572-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 251014470CA32BA6	FASTA	236	26,932
	10 20 30 40 50 60 MSPPNQDAQE GRPDSPTAEV VDVRRGMFGV SGTGDTSGYG RLVRQVVLPG SSPRPYGGYF 70 80 90 100 110 120 DDIVDRLAEA LRHERVEFED AVEKVVVYRD ELTLHVRRDL LPRVAQRLRD EPELRFELCL 130 140 150 160 170 180 GVSGVHYPHE TGRELHAVYP LQSITHNRRL RLEVSAPDSD PHIPSLFAIY PTNDWHERET 190 200 210 220 230 YDFFGIIFDG HPALTRIEMP DDWQGHPQRK DYPLGGIPVE YKGAQIPPPD ERRGYN

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248345 Genomic DNA. Translation: CAD95263.1.
RefSeq	NP_856816.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1093222.
GenomeReviews	Gene locus Mb3171 in contig BX248333_GR.
KEGG	mbo:Mb3171.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P65572.
Family and domain databases
InterPro	IPR010218. NADH_DH_csu. IPR001268. NADH_DHase_Ub_30kDa_su. [Graphical view]
Pfam	PF00329. Complex1_30kDa. 1 hit. [Graphical view]
ProDom	PD001581. Complex1_30K. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01961. NuoC_fam. 1 hit.
PROSITE	PS00542. COMPLEX1_30K. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUOC_MYCBO

Accession

Primary (citable) accession number: P65572
Secondary accession number(s): P95179

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 25, 2008
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)