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P65571 (NUOC_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit C
EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit C
NDH-1 subunit C
Gene names
Name:nuoC
Ordered Locus Names:Rv3147, MT3235
ORF Names:MTCY03A2.11c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length236 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01357

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP MF_01357

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex By similarity.

Subcellular location

Cell membrane; Peripheral membrane protein; Cytoplasmic side By similarity HAMAP MF_01357.

Sequence similarities

Belongs to the complex I 30 kDa subunit family.

Sequence caution

The sequence AAK47574.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   LigandNAD
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytosol

Inferred from direct assay. Source: MTBBASE

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 236236NADH-quinone oxidoreductase subunit C HAMAP MF_01357
PRO_0000118670

Sequences

Sequence LengthMass (Da)Tools
P65571 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 251014470CA32BA6

FASTA23626,932
        10         20         30         40         50         60 
MSPPNQDAQE GRPDSPTAEV VDVRRGMFGV SGTGDTSGYG RLVRQVVLPG SSPRPYGGYF 

        70         80         90        100        110        120 
DDIVDRLAEA LRHERVEFED AVEKVVVYRD ELTLHVRRDL LPRVAQRLRD EPELRFELCL 

       130        140        150        160        170        180 
GVSGVHYPHE TGRELHAVYP LQSITHNRRL RLEVSAPDSD PHIPSLFAIY PTNDWHERET 

       190        200        210        220        230 
YDFFGIIFDG HPALTRIEMP DDWQGHPQRK DYPLGGIPVE YKGAQIPPPD ERRGYN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842582 Genomic DNA. Translation: CAB06269.1.
AE000516 Genomic DNA. Translation: AAK47574.1. Different initiation.
PIRD70647.
RefSeqNP_217663.1. NC_000962.2.
NP_337760.1. NC_002755.2.

3D structure databases

ProteinModelPortalP65571.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000003939; EBMYCP00000003939; EBMYCG00000003937.
EBMYCT00000072316; EBMYCP00000070375; EBMYCG00000072311.
GeneID888816.
923382.
GenomeReviewsGene locus MT3235 in contig AE000516_GR.
Gene locus Rv3147 in contig AL123456_GR.
KEGGmtc:MT3235.
mtu:Rv3147.
PATRIC18128876. VBIMycTub22151_3535.
TIGRMT3235.

Organism-specific databases

TubercuListRv3147.

Phylogenomic databases

GeneTreeEBGT00050000017747.
HOGENOMHBG727675.
OMAPDQRRSY.
PhylomeDBP65571.
ProtClustDBPRK07785.

Family and domain databases

HAMAPMF_01357. NDH1_NuoC.
[Tree]
InterProIPR010218. NADH_DH_suC.
IPR001268. NADH_UbQ_OxRdtase_30kDa_su.
[Graphical view]
KOK00332.
PfamPF00329. Complex1_30kDa. 1 hit.
[Graphical view]
ProDomPD001581. NADH_UbQ_OxRdtase_30kDa_su. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01961. NuoC_fam. 1 hit.
PROSITEPS00542. COMPLEX1_30K. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOC_MYCTU
AccessionPrimary (citable) accession number: P65571
Secondary accession number(s): P95179
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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