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Reviewed, UniProtKB/Swiss-Prot P65567 (NUOF_MYCTU)

Last modified June 16, 2009. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-quinone oxidoreductase subunit F
    EC=1.6.99.5
Alternative name(s):
    NADH dehydrogenase I subunit F
    NDH-1 subunit F
Gene names
Name: nuoF
Ordered Locus Names: Rv3150, MT3238
ORF Names: MTCY03A2.08c
OrganismMycobacterium tuberculosis [Complete proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity.

Catalytic activity

NADH + quinone = NAD+ + quinol.

Cofactor

Binds 1 FMN Potential.

Binds 1 4Fe-4S cluster Potential.

Sequence similarities

Belongs to the complex I 51 kDa subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445NADH-quinone oxidoreductase subunit F
PRO_0000118574

Regions

Nucleotide binding61 – 7010NAD By similarity
Nucleotide binding177 – 22448FMN By similarity

Sites

Metal binding3531Iron-sulfur (4Fe-4S) Potential
Metal binding3561Iron-sulfur (4Fe-4S) Potential
Metal binding3591Iron-sulfur (4Fe-4S) Potential
Metal binding3991Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P65567-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: C02A660F43842926

FASTA44548,102
        10         20         30         40         50         60 
MTTQATPLTP VISRHWDDPE SWTLATYQRH DRYRGYQALQ KALTMPPDDV ISIVKDSGLR 

        70         80         90        100        110        120 
GRGGAGFATG TKWSFIPQGD TGAAAKPHYL VVNADESEPG TCKDIPLMLA TPHVLIEGVI 

       130        140        150        160        170        180 
IAAYAIRAHH AFVYVRGEVV PVLRRLHNAV AEAYAAGFLG RNIGGSGFDL ELVVHAGAGA 

       190        200        210        220        230        240 
YICGEETALL DSLEGRRGQP RLRPPFPAVA GLYGCPTVIN NVETIASVPS IILGGIDWFR 

       250        260        270        280        290        300 
SMGSEKSPGF TLYSLSGHVT RPGQYEAPLG ITLRELLDYA GGVRAGHRLK FWTPGGSSTP 

       310        320        330        340        350        360 
LLTDEHLDVP LDYEGVGAAG SMLGTKALEI FDETTCVVRA VRRWTEFYKH ESCGKCTPCR 

       370        380        390        400        410        420 
EGTFWLDKIY ERLETGRGSH EDIDKLLDIS DSILGKSFCA LGDGAASPVM SSIKHFRDEY 

       430        440 
LAHVEGGGCP FDPRDSMLVA NGVDA 

« Hide

Cross-references

Sequence databases

BX842582 Genomic DNA. Translation: CAB06289.1.
AE000516 Genomic DNA. Translation: AAK47577.1.
PIRG70647.
RefSeqNP_217666.1.
NP_337763.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID888854.
923375.
GenomeReviewsGene locus MT3238 in contig AE000516_GR.
Gene locus Rv3150 in contig AL123456_GR.
KEGGmtc:MT3238.
mtu:Rv3150.
TIGRMT3238.

Organism-specific databases

TubercuListRv3150.

Phylogenomic databases

HOGENOMP65567.
OMAP65567. AMPVRAM.

Enzyme and pathway databases

BRENDA1.6.99.5. 809.

Family and domain databases

InterProIPR001949. NADH-UbQ_OxRdtase_51KDa_CS.
IPR019575. NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
IPR011537. NADH-UbQ_OxRdtase_suF.
IPR011538. NADH_UbQ_OxRdtase_51KDa_su.
IPR019554. Soluble_ligand_bd.
[Graphical view]
PfamPF01512. Complex1_51K. 1 hit.
PF10589. NADH_4Fe-4S. 1 hit.
PF10531. SLBB. 1 hit.
[Graphical view]
TIGRFAMsTIGR01959. nuoF_fam. 1 hit.
PROSITEPS00644. COMPLEX1_51K_1. 1 hit.
PS00645. COMPLEX1_51K_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOF_MYCTU
AccessionPrimary (citable) accession number: P65567
Secondary accession number(s): P95176
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 16, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents