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P65563 (NUOA_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NADH-quinone oxidoreductase subunit A
EC=1.6.99.5
Alternative name(s):
NADH dehydrogenase I subunit A
NDH-1 subunit A
NUO1
Gene names
Name:nuoA
Ordered Locus Names:Rv3145, MT3233
ORF Names:MTCY03A2.13c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length128 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP MF_01394

Catalytic activity

NADH + quinone = NAD+ + quinol. HAMAP MF_01394

Subunit structure

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01394.

Sequence similarities

Belongs to the complex I subunit 3 family.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
   Molecular functionOxidoreductase
   PTMQuinone
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADH dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: InterPro

quinone binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 128128NADH-quinone oxidoreductase subunit A HAMAP MF_01394
PRO_0000117870

Regions

Transmembrane5 – 2521Helical; Potential
Transmembrane72 – 9221Helical; Potential
Transmembrane100 – 12021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
P65563 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: DDF4FD3F77A8149A

FASTA12813,975
        10         20         30         40         50         60 
MNVYIPILVL AALAAAFAVV SVVIASLVGP SRFNRSKQAA YECGIEPAST GARTSIGPGA 

        70         80         90        100        110        120 
ASGQRFPIKY YLTAMLFIVF DIEIVFLYPW AVSYDSLGTF ALVEMAIFML TVFVAYAYVW 


RRGGLTWD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842582 Genomic DNA. Translation: CAB06271.1.
AE000516 Genomic DNA. Translation: AAK47572.1.
PIRB70647.
RefSeqNP_217661.1. NC_000962.2.
NP_337758.1. NC_002755.2.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000003713; EBMYCP00000003713; EBMYCG00000003711.
EBMYCT00000071567; EBMYCP00000069626; EBMYCG00000071562.
GeneID887397.
923389.
GenomeReviewsGene locus MT3233 in contig AE000516_GR.
Gene locus Rv3145 in contig AL123456_GR.
KEGGmtc:MT3233.
mtu:Rv3145.
PATRIC18128872. VBIMycTub22151_3533.
TIGRMT3233.

Organism-specific databases

TubercuListRv3145.

Phylogenomic databases

GeneTreeEBGT00050000016339.
HOGENOMHBG605540.
OMAIGFAYEW.
PhylomeDBP65563.
ProtClustDBPRK07928.

Family and domain databases

HAMAPMF_01394. NDH1_NuoA.
[Tree]
InterProIPR023043. NAD(P)H_OxRDtase_bac/plastid.
IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3.
[Graphical view]
KOK00330.
PANTHERPTHR11058. Oxidored_q4. 1 hit.
PfamPF00507. Oxidored_q4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNUOA_MYCTU
AccessionPrimary (citable) accession number: P65563
Secondary accession number(s): P95181
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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