Reviewed,
UniProtKB/Swiss-Prot P65563 (NUOA_MYCTU)
Last modified
November 25, 2008.
Version 27.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: NADH-quinone oxidoreductase subunit A EC=1.6.99.5 Alternative name(s): NADH dehydrogenase I subunit A NDH-1 subunit A | ||||||
| Gene names |
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| Organism | Mycobacterium tuberculosis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1773 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex |
Protein attributes
| Sequence length | 128 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. |
| Catalytic activity | NADH + quinone = NAD(+) + quinol. |
| Subcellular location | |
| Sequence similarities | Belongs to the complex I subunit 3 family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| PTM | Quinone |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | mitochondrial electron transport, NADH to ubiquinone Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G.Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv. |
| [2] | "Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M.J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh. |
Cross-references
Sequence databases | |
|---|---|
| BX842582 Genomic DNA. Translation: CAB06271.1. AE000516 Genomic DNA. Translation: AAK47572.1. | |
| PIR | B70647. |
| RefSeq | NP_217661.1. NP_337758.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 887397. 923389. |
| GenomeReviews | Gene locus MT3233 in contig AE000516_GR. Gene locus Rv3145 in contig AL123456_GR. |
| KEGG | mtc:MT3233. mtu:Rv3145. |
| TIGR | MT3233. |
Organism-specific databases | |
| TubercuList | Rv3145. |
Phylogenomic databases | |
| HOGENOM | P65563. |
Family and domain databases | |
| InterPro | IPR000440. Oxidored_q4. [Graphical view] |
| PANTHER | PTHR11058. Oxidored_q4. 1 hit. |
| Pfam | PF00507. Oxidored_q4. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NUOA_MYCTU | ||||||||
| Accession | Primary (citable) accession number: P65563 Secondary accession number(s): P95181 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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