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Protein

Uncharacterized Nudix hydrolase YfcD

Gene

yfcD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi88Magnesium1
Metal bindingi92MagnesiumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7191-MONOMER.
ECOL316407:JW2296-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized Nudix hydrolase YfcD (EC:3.6.-.-)
Gene namesi
Name:yfcD
Ordered Locus Names:b2299, JW2296
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14107. yfcD.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000570771 – 180Uncharacterized Nudix hydrolase YfcDAdd BLAST180

Proteomic databases

PaxDbiP65556.
PRIDEiP65556.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
panCP316635EBI-545346,EBI-545354

Protein-protein interaction databases

BioGridi4260514. 13 interactors.
DIPiDIP-28086N.
IntActiP65556. 4 interactors.
STRINGi511145.b2299.

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi11 – 15Combined sources5
Beta strandi21 – 26Combined sources6
Helixi27 – 33Combined sources7
Beta strandi37 – 45Combined sources9
Beta strandi47 – 49Combined sources3
Beta strandi51 – 56Combined sources6
Beta strandi61 – 63Combined sources3
Beta strandi67 – 71Combined sources5
Helixi81 – 93Combined sources13
Beta strandi101 – 110Combined sources10
Beta strandi113 – 123Combined sources11
Turni132 – 134Combined sources3
Beta strandi135 – 141Combined sources7
Helixi143 – 147Combined sources5
Helixi148 – 152Combined sources5
Helixi155 – 167Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FKBX-ray2.00A/B/C1-180[»]
ProteinModelPortaliP65556.
SMRiP65556.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP65556.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 163Nudix hydrolasePROSITE-ProRule annotationAdd BLAST129

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi72 – 94Nudix boxAdd BLAST23

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105PTV. Bacteria.
ENOG410ZCV3. LUCA.
HOGENOMiHOG000274108.
InParanoidiP65556.
OMAiGYWDVAA.
PhylomeDBiP65556.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR024195. NUDIX_hydrolase_YfcD_pred.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PIRSFiPIRSF017340. Nudix_hydro. 1 hit.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQRRLASTE WVDIVNEENE VIAQASREQM RAQCLRHRAT YIVVHDGMGK
60 70 80 90 100
ILVQRRTETK DFLPGMLDAT AGGVVQADEQ LLESARREAE EELGIAGVPF
110 120 130 140 150
AEHGQFYFED KNCRVWGALF SCVSHGPFAL QEDEVSEVCW LTPEEITARC
160 170 180
DEFTPDSLKA LALWMKRNAK NEAVETETAE
Length:180
Mass (Da):20,376
Last modified:October 11, 2004 - v1
Checksum:i83FC88B71EF9D58B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75359.1.
AP009048 Genomic DNA. Translation: BAE76686.1.
PIRiA65002.
RefSeqiNP_416802.1. NC_000913.3.
WP_000437935.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75359; AAC75359; b2299.
BAE76686; BAE76686; BAE76686.
GeneIDi946783.
KEGGiecj:JW2296.
eco:b2299.
PATRICi32119969. VBIEscCol129921_2394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75359.1.
AP009048 Genomic DNA. Translation: BAE76686.1.
PIRiA65002.
RefSeqiNP_416802.1. NC_000913.3.
WP_000437935.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FKBX-ray2.00A/B/C1-180[»]
ProteinModelPortaliP65556.
SMRiP65556.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260514. 13 interactors.
DIPiDIP-28086N.
IntActiP65556. 4 interactors.
STRINGi511145.b2299.

Proteomic databases

PaxDbiP65556.
PRIDEiP65556.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75359; AAC75359; b2299.
BAE76686; BAE76686; BAE76686.
GeneIDi946783.
KEGGiecj:JW2296.
eco:b2299.
PATRICi32119969. VBIEscCol129921_2394.

Organism-specific databases

EchoBASEiEB3860.
EcoGeneiEG14107. yfcD.

Phylogenomic databases

eggNOGiENOG4105PTV. Bacteria.
ENOG410ZCV3. LUCA.
HOGENOMiHOG000274108.
InParanoidiP65556.
OMAiGYWDVAA.
PhylomeDBiP65556.

Enzyme and pathway databases

BioCyciEcoCyc:G7191-MONOMER.
ECOL316407:JW2296-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP65556.
PROiP65556.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
IPR024195. NUDIX_hydrolase_YfcD_pred.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
PIRSFiPIRSF017340. Nudix_hydro. 1 hit.
SUPFAMiSSF55811. SSF55811. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYFCD_ECOLI
AccessioniPrimary (citable) accession number: P65556
Secondary accession number(s): P76494, Q2MAM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.