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Protein

Uncharacterized Nudix hydrolase YfcD

Gene

yfcD

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi88Magnesium1
Metal bindingi92MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7191-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized Nudix hydrolase YfcD (EC:3.6.-.-)
Gene namesi
Name:yfcD
Ordered Locus Names:b2299, JW2296
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14107 yfcD

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000570771 – 180Uncharacterized Nudix hydrolase YfcDAdd BLAST180

Proteomic databases

PaxDbiP65556
PRIDEiP65556

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
panCP316636EBI-545346,EBI-545354

Protein-protein interaction databases

BioGridi4260514, 14 interactors
DIPiDIP-28086N
IntActiP65556, 5 interactors
STRINGi316385.ECDH10B_2461

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi11 – 15Combined sources5
Beta strandi21 – 26Combined sources6
Helixi27 – 33Combined sources7
Beta strandi37 – 45Combined sources9
Beta strandi47 – 49Combined sources3
Beta strandi51 – 56Combined sources6
Beta strandi61 – 63Combined sources3
Beta strandi67 – 71Combined sources5
Helixi81 – 93Combined sources13
Beta strandi101 – 110Combined sources10
Beta strandi113 – 123Combined sources11
Turni132 – 134Combined sources3
Beta strandi135 – 141Combined sources7
Helixi143 – 147Combined sources5
Helixi148 – 152Combined sources5
Helixi155 – 167Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FKBX-ray2.00A/B/C1-180[»]
ProteinModelPortaliP65556
SMRiP65556
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP65556

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 163Nudix hydrolasePROSITE-ProRule annotationAdd BLAST129

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi72 – 94Nudix boxAdd BLAST23

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiENOG4105PTV Bacteria
ENOG410ZCV3 LUCA
HOGENOMiHOG000274108
InParanoidiP65556
OMAiPGYWDVA
PhylomeDBiP65556

Family and domain databases

InterProiView protein in InterPro
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
IPR024195 NUDIX_hydrolase_YfcD_pred
PfamiView protein in Pfam
PF00293 NUDIX, 1 hit
PIRSFiPIRSF017340 Nudix_hydro, 1 hit
SUPFAMiSSF55811 SSF55811, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequencei

Sequence statusi: Complete.

P65556-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQRRLASTE WVDIVNEENE VIAQASREQM RAQCLRHRAT YIVVHDGMGK
60 70 80 90 100
ILVQRRTETK DFLPGMLDAT AGGVVQADEQ LLESARREAE EELGIAGVPF
110 120 130 140 150
AEHGQFYFED KNCRVWGALF SCVSHGPFAL QEDEVSEVCW LTPEEITARC
160 170 180
DEFTPDSLKA LALWMKRNAK NEAVETETAE
Length:180
Mass (Da):20,376
Last modified:October 11, 2004 - v1
Checksum:i83FC88B71EF9D58B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC75359.1
AP009048 Genomic DNA Translation: BAE76686.1
PIRiA65002
RefSeqiNP_416802.1, NC_000913.3
WP_000437935.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC75359; AAC75359; b2299
BAE76686; BAE76686; BAE76686
GeneIDi946783
KEGGiecj:JW2296
eco:b2299
PATRICifig|511145.12.peg.2394

Similar proteinsi

Entry informationi

Entry nameiYFCD_ECOLI
AccessioniPrimary (citable) accession number: P65556
Secondary accession number(s): P76494, Q2MAM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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