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P65506 (NADE_STAAM) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NH(3)-dependent NAD(+) synthetase
EC=6.3.1.5
Gene names
Name:nadE
Ordered Locus Names:SAV1912
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193

Sequence similarities

Belongs to the NAD synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273NH(3)-dependent NAD(+) synthetase HAMAP MF_00193
PRO_0000152195

Regions

Nucleotide binding47 – 548ATP By similarity

Sites

Active site491 By similarity

Sequences

Sequence LengthMass (Da)Tools
P65506 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: EB4A022F38247F08

FASTA27330,683
        10         20         30         40         50         60 
MSKLQDVIVQ EMKVKKRIDS AEEIMELKQF IKNYVQSHSF IKSLVLGISG GQDSTLVGKL 

        70         80         90        100        110        120 
VQMSVNELRE EGIDCTFIAV KLPYGVQKDA DEVDQALRFI EPDEIVTVNI KPAVDQSVQS 

       130        140        150        160        170        180 
LKEAGIVLTD FQKGNEKARE RMKVQFSIAS NRQGIVVGTD HSAENITGFY TKYGDGAADI 

       190        200        210        220        230        240 
APIFGLNKRQ GRQLLAYLGA PKELYEKTPT ADLEDDKPQL PDEDALGVTY EAIDNYLEGK 

       250        260        270 
PVTPEEQKVI ENHYIRNAHK RELAYTRYTW PKS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000017 Genomic DNA. Translation: BAB58074.1.
RefSeqNP_372436.1. NC_002758.2.

3D structure databases

ProteinModelPortalP65506.
SMRP65506. Positions 4-268.
ModBaseSearch...

Protein-protein interaction databases

STRINGP65506.

2D gel databases

World-2DPAGE0002:P65506.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000006492; EBSTAP00000006310; EBSTAG00000006491.
GeneID1121925.
GenomeReviewsGene locus SAV1912 in contig BA000017_GR.
KEGGsav:SAV1912.
PATRIC19564680. VBIStaAur52173_1980.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0171.
GeneTreeEBGT00050000025036.
HOGENOMHBG351567.
OMAIAQYEIA.
ProtClustDBPRK00768.

Enzyme and pathway databases

BioCycSAUR158878:SAV1912-MONOMER.

Family and domain databases

HAMAPMF_00193. NadE.
[Tree]
InterProIPR022310. NAD/GMP_synthase.
IPR003694. NAD_synthase.
IPR022926. NH(3)-dep_NAD(+)_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01916.
PfamPF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00552. NadE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADE_STAAM
AccessionPrimary (citable) accession number: P65506
Secondary accession number(s): Q99SX5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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