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P65500 (NADB_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
L-aspartate oxidase
Short name=LASPO
EC=1.4.3.16
Alternative name(s):
Quinolinate synthase B
Gene names
Name:nadB
Ordered Locus Names:Mb1621
OrganismMycobacterium bovis [Complete proteome] [HAMAP]
Taxonomic identifier1765 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activity

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactor

FAD.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-aspartate oxidase activity

Inferred from electronic annotation. Source: EC

L-aspartate:fumarate oxidoreductase activity

Inferred from electronic annotation. Source: EC

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527L-aspartate oxidase
PRO_0000184390

Regions

Nucleotide binding13 – 2715FAD Potential

Sites

Active site2331 By similarity
Active site2541 By similarity

Sequences

Sequence LengthMass (Da)Tools
P65500 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 5494D354B107E5DA

FASTA52753,785
        10         20         30         40         50         60 
MAGPAWRDAA DVVVIGTGVA GLAAALAADR AGRSVVVLSK AAQTHVTATH YAQGGIAVVL 

        70         80         90        100        110        120 
PDNDDSVDAH VADTLAAGAG LCDPDAVYSI VADGYRAVTD LVGAGARLDE SVPGRWALTR 

       130        140        150        160        170        180 
EGGHSRRRIV HAGGDATGAE VQRALQDAAG MLDIRTGHVA LRVLHDGTAV TGLLVVRPDG 

       190        200        210        220        230        240 
CGIISAPSVI LATGGLGHLY SATTNPAGST GDGIALGLWA GVAVSDLEFI QFHPTMLFAG 

       250        260        270        280        290        300 
RAGGRRPLIT EAIRGEGAIL VDRQGNSITA GVHPMGDLAP RDVVAAAIDA RLKATGDPCV 

       310        320        330        340        350        360 
YLDARGIEGF ASRFPTVTAS CRAAGIDPVR QPIPVVPGAH YSCGGIVTDV YGQTELLGLY 

       370        380        390        400        410        420 
AAGEVARTGL HGANRLASNS LLEGLVVGGR AGKAAAAHAA AAGRSRATSS ATWPEPISYT 

       430        440        450        460        470        480 
ALDRGDLQRA MSRDASMYRA AAGLHRLCDS LSGAQVRDVA CRRDFEDVAL TLVAQSVTAA 

       490        500        510        520 
ALARTESRGC HHRAEYPCTV PEQARSIVVR GADDANAVCV QALVAVC

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX248339 Genomic DNA. Translation: CAD96289.1.
RefSeqNP_855274.1. NC_002945.3.

3D structure databases

ProteinModelPortalP65500.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000016163; EBMYCP00000015998; EBMYCG00000016158.
GeneID1092510.
GenomeReviewsGene locus Mb1621 in contig BX248333_GR.
KEGGmbo:Mb1621.
PATRIC18005245. VBIMycBov88188_1770.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000015552.
HOGENOMHBG293998.
OMAGAYIWNR.
ProtClustDBPRK07804.

Enzyme and pathway databases

BioCycMBOV233413:MB1621-MONOMER.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR004112. Fum_Rdtase/Succ_DH_flav_C.
IPR005288. NadB.
[Graphical view]
Gene3DG3DSA:1.20.58.100. Fum_Rdtase/Succ_DH_flav-like_C. 1 hit.
KOK00278.
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF46977. Succ_DH_flav_C. 1 hit.
TIGRFAMsTIGR00551. NadB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADB_MYCBO
AccessionPrimary (citable) accession number: P65500
Secondary accession number(s): O06595
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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