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Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutLUniRule annotation
Gene namesi
Name:mutLUniRule annotation
Ordered Locus Names:SAV1297
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001779691 – 669DNA mismatch repair protein MutLAdd BLAST669

Proteomic databases

PaxDbiP65491.

2D gel databases

World-2DPAGE0002:P65491.

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1297.

Structurei

3D structure databases

ProteinModelPortaliP65491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutL/HexB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DC6. Bacteria.
COG0323. LUCA.
HOGENOMiHOG000256552.
KOiK03572.
OMAiQFLFINN.
PhylomeDBiP65491.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPiMF_00149. DNA_mis_repair. 1 hit.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR028831. Pms1/Pms2/PMS2L.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10073:SF12. PTHR10073:SF12. 1 hit.
PfamiPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIKELQTS LANKIAAGEV VERPSSVVKE LLENAIDAGA TEISIEVEES
60 70 80 90 100
GVQSIRVVDN GSGIEAEDLG LVFHRHATSK LDQDEDLFHI RTLGFRGEAL
110 120 130 140 150
ASISSVAKVT LKTCTDNANG NEIYVENGEI LNHKPAKAKK GTDILVESLF
160 170 180 190 200
YNTPARLKYI KSLYTELGKI TDIVNRMAMS HPDIRIALIS DGKTMLSTNG
210 220 230 240 250
SGRTNEVMAE IYGMKVARDL VHISGDTSDY HIEGFVAKPE HSRSNKHYIS
260 270 280 290 300
IFINGRYIKN FMLNKAILEG YHTLLTIGRF PICYINIEMD PILVDVNVHP
310 320 330 340 350
TKLEVRLSKE EQLYQLIVSK IQEAFKDRIL IPKNNLDYVP KKNKVLYSFE
360 370 380 390 400
QQKIEFEQRQ NTENNQEKTF SSEESNSKSF MAENQNDEIV IKEDSYNPFV
410 420 430 440 450
TKTSESLITD DESSGYNNTR EKDEDYFKKQ QEILQEMDQT FDSNEDASVQ
460 470 480 490 500
NYENKASDDY YDVNDIKGTK SKDPKRRIPY MEIVGQVHGT YIIAQNEFGM
510 520 530 540 550
YMIDQHAAQE RIKYEYFRDK IGEVTNEVQD LLIPLTFHFS KDEQLVIDQY
560 570 580 590 600
KNELQQVGIM LEHFGGHDYI VSSYPVWFPK DEVEEIIKDM IELILEEKKV
610 620 630 640 650
DIKKLREDVA IMMSCKKSIK ANHYLQKHEM SDLIDQLREA EDPFTCPHGR
660
PIIINFSKYE LEKLFKRVM
Length:669
Mass (Da):76,871
Last modified:October 11, 2004 - v1
Checksum:i2EDC1F88D24CC6D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57459.1.
RefSeqiWP_000516269.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB57459; BAB57459; SAV1297.
KEGGisav:SAV1297.
PATRICi19563305. VBIStaAur52173_1330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB57459.1.
RefSeqiWP_000516269.1. NC_002758.2.

3D structure databases

ProteinModelPortaliP65491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV1297.

2D gel databases

World-2DPAGE0002:P65491.

Proteomic databases

PaxDbiP65491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB57459; BAB57459; SAV1297.
KEGGisav:SAV1297.
PATRICi19563305. VBIStaAur52173_1330.

Phylogenomic databases

eggNOGiENOG4105DC6. Bacteria.
COG0323. LUCA.
HOGENOMiHOG000256552.
KOiK03572.
OMAiQFLFINN.
PhylomeDBiP65491.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPiMF_00149. DNA_mis_repair. 1 hit.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR002099. DNA_mismatch_repair_fam.
IPR020667. DNA_mismatch_repair_MutL.
IPR003594. HATPase_C.
IPR014790. MutL_C.
IPR028831. Pms1/Pms2/PMS2L.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10073:SF12. PTHR10073:SF12. 1 hit.
PfamiPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
TIGRFAMsiTIGR00585. mutl. 1 hit.
PROSITEiPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMUTL_STAAM
AccessioniPrimary (citable) accession number: P65491
Secondary accession number(s): Q99UH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.