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Protein

DNA mismatch repair protein MutL

Gene

mutL

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutLUniRule annotation
Gene namesi
Name:mutLUniRule annotation
Ordered Locus Names:SAV1297
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001779691 – 669DNA mismatch repair protein MutLAdd BLAST669

Proteomic databases

PaxDbiP65491
PRIDEiP65491

2D gel databases

World-2DPAGE0002:P65491

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV1297

Structurei

3D structure databases

ProteinModelPortaliP65491
SMRiP65491
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutL/HexB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DC6 Bacteria
COG0323 LUCA
HOGENOMiHOG000256552
KOiK03572
OMAiQHIAHER
PhylomeDBiP65491

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
Gene3Di3.30.230.10, 1 hit
3.30.565.10, 1 hit
HAMAPiMF_00149 DNA_mis_repair, 1 hit
InterProiView protein in InterPro
IPR014762 DNA_mismatch_repair_CS
IPR020667 DNA_mismatch_repair_MutL
IPR002099 DNA_mismatch_repair_N
IPR013507 DNA_mismatch_S5_2-like
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR038973 MutL/Mlh/Pms
IPR014790 MutL_C
IPR037198 MutL_C_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR10073 PTHR10073, 1 hit
PfamiView protein in Pfam
PF01119 DNA_mis_repair, 1 hit
PF08676 MutL_C, 1 hit
SMARTiView protein in SMART
SM01340 DNA_mis_repair, 1 hit
SM00853 MutL_C, 1 hit
SUPFAMiSSF118116 SSF118116, 1 hit
SSF54211 SSF54211, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00585 mutl, 1 hit
PROSITEiView protein in PROSITE
PS00058 DNA_MISMATCH_REPAIR_1, 1 hit

Sequencei

Sequence statusi: Complete.

P65491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIKELQTS LANKIAAGEV VERPSSVVKE LLENAIDAGA TEISIEVEES
60 70 80 90 100
GVQSIRVVDN GSGIEAEDLG LVFHRHATSK LDQDEDLFHI RTLGFRGEAL
110 120 130 140 150
ASISSVAKVT LKTCTDNANG NEIYVENGEI LNHKPAKAKK GTDILVESLF
160 170 180 190 200
YNTPARLKYI KSLYTELGKI TDIVNRMAMS HPDIRIALIS DGKTMLSTNG
210 220 230 240 250
SGRTNEVMAE IYGMKVARDL VHISGDTSDY HIEGFVAKPE HSRSNKHYIS
260 270 280 290 300
IFINGRYIKN FMLNKAILEG YHTLLTIGRF PICYINIEMD PILVDVNVHP
310 320 330 340 350
TKLEVRLSKE EQLYQLIVSK IQEAFKDRIL IPKNNLDYVP KKNKVLYSFE
360 370 380 390 400
QQKIEFEQRQ NTENNQEKTF SSEESNSKSF MAENQNDEIV IKEDSYNPFV
410 420 430 440 450
TKTSESLITD DESSGYNNTR EKDEDYFKKQ QEILQEMDQT FDSNEDASVQ
460 470 480 490 500
NYENKASDDY YDVNDIKGTK SKDPKRRIPY MEIVGQVHGT YIIAQNEFGM
510 520 530 540 550
YMIDQHAAQE RIKYEYFRDK IGEVTNEVQD LLIPLTFHFS KDEQLVIDQY
560 570 580 590 600
KNELQQVGIM LEHFGGHDYI VSSYPVWFPK DEVEEIIKDM IELILEEKKV
610 620 630 640 650
DIKKLREDVA IMMSCKKSIK ANHYLQKHEM SDLIDQLREA EDPFTCPHGR
660
PIIINFSKYE LEKLFKRVM
Length:669
Mass (Da):76,871
Last modified:October 11, 2004 - v1
Checksum:i2EDC1F88D24CC6D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB57459.1
RefSeqiWP_000516269.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB57459; BAB57459; SAV1297
KEGGisav:SAV1297

Similar proteinsi

Entry informationi

Entry nameiMUTL_STAAM
AccessioniPrimary (citable) accession number: P65491
Secondary accession number(s): Q99UH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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