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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei176UniRule annotation1
Active sitei226Proton donorUniRule annotation1
Active sitei296UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:SA0693
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001792581 – 307UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST307

Structurei

3D structure databases

ProteinModelPortaliP65463
SMRiP65463
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 197FAD-binding PCMH-typeUniRule annotationAdd BLAST165

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000284355
KOiK00075
OMAiIGNAGSF

Family and domain databases

Gene3Di3.30.43.10, 1 hit
3.90.78.10, 1 hit
HAMAPiMF_00037 MurB, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR003170 MurB
IPR011601 MurB_C
IPR036635 MurB_C_sf
IPR006094 Oxid_FAD_bind_N
PANTHERiPTHR21071 PTHR21071, 1 hit
PfamiView protein in Pfam
PF01565 FAD_binding_4, 1 hit
PF02873 MurB_C, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
SSF56194 SSF56194, 1 hit
TIGRFAMsiTIGR00179 murB, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

P65463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINKDIYQAL QQLIPNEKIK VDEPLKRYTY TKTGGNADFY ITPTKNEEVQ
60 70 80 90 100
AVVKYAYQNE IPVTYLGNGS NIIIREGGIR GIVISLLSLD HIDVSDDAII
110 120 130 140 150
AGSGAAIIDV SRVARDYALT GLEFACGIPG SIGGAVYMNA GAYGGEVKDC
160 170 180 190 200
IDYALCVNEQ GSLIKLTTKE LELDYRNSII QKEHLVVLEA AFTLAPGKMT
210 220 230 240 250
EIQAKMDDLT ERRESKQPLE YPSCGSVFQR PPGHFAGKLI QDSNLQGHRI
260 270 280 290 300
GGVEVSTKHA GFMVNVDNGT ATDYENLIHY VQKTVKEKFG IELNREVRII

GEHPKES
Length:307
Mass (Da):33,783
Last modified:October 11, 2004 - v1
Checksum:i74479E995C4AF07B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA Translation: BAB41926.1
PIRiC89846
RefSeqiWP_000608433.1, NC_002745.2

Genome annotation databases

EnsemblBacteriaiBAB41926; BAB41926; BAB41926
KEGGisau:SA0693

Similar proteinsi

Entry informationi

Entry nameiMURB_STAAN
AccessioniPrimary (citable) accession number: P65463
Secondary accession number(s): Q99VN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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