Reviewed, UniProtKB/Swiss-Prot P65447 (MSRB_BRUME)

Names and origin

Protein names

Recommended name:
    Peptide methionine sulfoxide reductase msrB
    EC=1.8.4.12
Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	BMEII0819

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

29459 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Sequence similarities	Belongs to the msrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Peptide methionine sulfoxide reductase msrB HAMAP MF_01400		PRO_0000140264
Sites
	Active site	118	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	P65447-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 9FC96BF58F4A702B	FASTA	146	16,281
	10 20 30 40 50 60 MKYQKSAEAI AKLSAEQYRV TQENGTERPG TGEYLYNKEP GIYVDIVSGE PLFASSDKYE 70 80 90 100 110 120 SHCGWPSFTK PIERANVTEL TDMSHGMVRT EVRSAHGDSH LGHVFPDGPV DRGGLRYCIN 130 140 SASLRFVPKD RMEAEGYGDY LDQVEG

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008918 Genomic DNA. Translation: AAL54061.1.
PIR	AB3612.
RefSeq	NP_541797.1.
3D structure databases
HSSP	HSSP built from PDB template 1L1D based on UniProtKB P14930.
ModBase	Search...
Genome annotation databases
GeneID	1198591.
GenomeReviews	Gene locus BMEII0819 in contig AE008918_GR.
KEGG	bme:BMEII0819.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P65447.
OMA	KYESGCG.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEII0819-MON.
BRENDA	1.8.4.12. 277959.
Family and domain databases
HAMAP	MF_01400. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
ProDom	PD004057. DUF25. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00357. MsrB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_BRUME

Accession

Primary (citable) accession number: P65447
Secondary accession number(s): Q8YBR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)