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P65443 (MSAB2_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA/MsrB 2

Including the following 2 domains:

  1. Peptide methionine sulfoxide reductase MsrA
    Short name=Protein-methionine-S-oxide reductase
    EC=1.8.4.11
    Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase
    Short name=Peptide Met(O) reductase
  2. Peptide methionine sulfoxide reductase MsrB
    EC=1.8.4.12
    Alternative name(s):
    Peptide-methionine (R)-S-oxide reductase
Gene names
Name:msrAB2
Synonyms:msrA
Ordered Locus Names:SP_0660
OrganismStreptococcus pneumoniae [Complete proteome] [HAMAP]
Taxonomic identifier1313 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01400

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01400

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.

Sequence similarities

In the N-terminal section; belongs to the MsrA Met sulfoxide reductase family.

In the C-terminal section; belongs to the MsrB Met sulfoxide reductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311Peptide methionine sulfoxide reductase MsrA/MsrB 2 HAMAP MF_01400
PRO_0000138519

Regions

Region1 – 155155Peptide methionine sulfoxide reductase A HAMAP MF_01400
Region172 – 295124Peptide methionine sulfoxide reductase B HAMAP MF_01400

Sites

Active site101 By similarity
Active site2841 By similarity

Sequences

Sequence LengthMass (Da)Tools
P65443 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 712B56F23489A40E

FASTA31135,610
        10         20         30         40         50         60 
MHEIYLAGGC FWGVEEYFSR VPGVTDAVSG YANGRGETTK YELINQTGHA ETVHVTYDAK 

        70         80         90        100        110        120 
QISLKEILLH YFRIINPTSK NKQGNDVGTQ YRTGVYYTDD KDLEVINQVF DEVAKKYDQP 

       130        140        150        160        170        180 
LAVEKENLKN FVVAEDYHQD YLKKNPNGYC HINVNQAAYP VIDASKYPKP SDEELKKTLS 

       190        200        210        220        230        240 
PEEYAVTQEN QTERAFSNRY WDKFESGIYV DIATGEPLFS SKDKFESGCG WPSFTQPISP 

       250        260        270        280        290        300 
DVVTYKEDKS YNMTRMEVRS RVGDSHLGHV FTDGPQDKGG LRYCINSLSI RFIPKDQMEE 

       310 
KGYAYLLDYV D

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005672 Genomic DNA. Translation: AAK74805.1.
PIRD95076.
RefSeqNP_345165.1. NC_003028.3.

3D structure databases

ProteinModelPortalP65443.
SMRP65443. Positions 4-161, 164-306.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000026329; EBSTRP00000025421; EBSTRG00000026329.
GeneID930609.
GenomeReviewsGene locus SP_0660 in contig AE005672_GR.
KEGGspn:SP_0660.
PATRIC19705685. VBIStrPne105772_0689.
TIGRSP_0660.

Phylogenomic databases

GeneTreeEBGT00050000027538.
HOGENOMHBG715255.
OMAGIYYTDK.
ProtClustDBCLSK2752092.

Enzyme and pathway databases

BioCycSPNE170187-1:SP_0660-MONOMER.

Family and domain databases

HAMAPMF_01400. MsrB. Fused.
[Tree]
MF_01401. MsrA. Fused.
[Tree]
InterProIPR002579. Methionine_sulphoxide_MsrB.
IPR011057. Mss4-like.
IPR002569. Peptide_Met_Sox_Rdtase_MsrA.
[Graphical view]
Gene3DG3DSA:3.30.1060.10. MsrA. 1 hit.
G3DSA:2.170.150.20. MsrB. 1 hit.
KOK12267.
PfamPF01625. PMSR. 1 hit.
PF01641. SelR. 1 hit.
[Graphical view]
SUPFAMSSF55068. MsrA. 1 hit.
SSF51316. Mss4_like. 1 hit.
TIGRFAMsTIGR00401. MsrA. 1 hit.
TIGR00357. TIGR00357. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSAB2_STRPN
AccessionPrimary (citable) accession number: P65443
Secondary accession number(s): Q97RX3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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