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P65423 (MQO1_STAAW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable malate:quinone oxidoreductase 1
EC=1.1.5.4
Alternative name(s):
MQO 1
Malate dehydrogenase [quinone] 1
Gene names
Name:mqo1
Ordered Locus Names:MW2286
OrganismStaphylococcus aureus (strain MW2) [Complete proteome] [HAMAP]
Taxonomic identifier196620 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212

Cofactor

FAD By similarity. HAMAP MF_00212

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212

Sequence similarities

Belongs to the MQO family.

Sequence caution

The sequence BAB96151.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionmalate dehydrogenase (menaquinone) activity

Inferred from electronic annotation. Source: EC

malate dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Probable malate:quinone oxidoreductase 1 HAMAP MF_00212
PRO_0000128747

Sequences

Sequence LengthMass (Da)Tools
P65423 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 8D31D1A84F26D441

FASTA49254,786
        10         20         30         40         50         60 
MTTQHSKTDV ILIGGGIMSA TLGTLLKELS PEKNIKVFEK LAQPGEESSN VWNNAGTGHS 

        70         80         90        100        110        120 
ALCELNYTKE GKDGTVDCSK AIKINEQYQI SKQFWAYLVK TGQLDNPDRF IQAVPHMSFV 

       130        140        150        160        170        180 
IGEDNVAFIK SRVATLKKSV LFEKMKLSQD EEEMKSWVPL MIEGRKSDEP IALTYDETGT 

       190        200        210        220        230        240 
DVNFGALTAK LFENLEQRGV GIQYKQNVLD IKKQKSGAWL VKVKDLETNE TTTYESDFVF 

       250        260        270        280        290        300 
IGAGGASLPL LQKTGIKQSK HIGGFPVSGL FLRCTNQEVI DRHHAKVYGK AAVGAPPMSV 

       310        320        330        340        350        360 
PHLDTRFVDG KRSLLFGPFA GFSPKFLKTG SHMDLIKSVK PNNIVTMLSA GIKEMSLTKY 

       370        380        390        400        410        420 
LVSQLMLSND ERMDDLRVFF PNAKNEDWEV ITAGQRVQVI KDTEDSKGNL QFGTEVITSD 

       430        440        450        460        470        480 
DGTLAALLGA SPGASTAVDI MFDVLQRCYR DEFKGWEPKI KEMVPSFGYR LTDHEDLYHK 

       490 
INEEVTKYLQ VK

« Hide

References

[1]"Genome and virulence determinants of high virulence community-acquired MRSA."
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.
Lancet 359:1819-1827(2002) [PubMed: 12044378] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MW2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000033 Genomic DNA. Translation: BAB96151.1. Different initiation.
RefSeqNP_647103.1. NC_003923.1.

3D structure databases

ProteinModelPortalP65423.
ModBaseSearch...

Protein-protein interaction databases

STRINGP65423.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000027317; EBSTAP00000026356; EBSTAG00000027316.
GeneID1004422.
GenomeReviewsGene locus MW2286 in contig BA000033_GR.
KEGGsam:MW2286.
PATRIC19571306. VBIStaAur44266_2363.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0579.
GeneTreeEBGT00050000024300.
HOGENOMHBG289663.
ProtClustDBPRK05257.

Enzyme and pathway databases

BioCycSAUR196620:MW2286-MONOMER.

Family and domain databases

HAMAPMF_00212. MQO.
[Tree]
InterProIPR006231. Malate_quinone_OxRdtase.
[Graphical view]
KOK00116.
PANTHERPTHR13847:SF14. PTHR13847:SF14. 1 hit.
PfamPF06039. Mqo. 1 hit.
[Graphical view]
TIGRFAMsTIGR01320. Mal_quin_oxido. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMQO1_STAAW
AccessionPrimary (citable) accession number: P65423
Secondary accession number(s): Q99RR2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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