Reviewed, UniProtKB/Swiss-Prot P65422 (MQO1_STAAN)

Names and origin

Protein names

Recommended name:
    Probable malate:quinone oxidoreductase 1
    EC=1.1.99.16
Alternative name(s):
    Malate dehydrogenase [acceptor] 1
    MQO 1

Gene names

Name:	mqo1
Ordered Locus Names:	SA2155

Organism

Staphylococcus aureus (strain N315) [Complete proteome] [HAMAP]

Taxonomic identifier

158879 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	(S)-malate + acceptor = oxaloacetate + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle.
Sequence similarities	Belongs to the MQO family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	malate dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	Probable malate:quinone oxidoreductase 1		PRO_0000128741

Sequences

	Sequence		Length	Mass (Da)
	P65422-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 8D31D1A84F26D441	FASTA	492	54,786
	10 20 30 40 50 60 MTTQHSKTDV ILIGGGIMSA TLGTLLKELS PEKNIKVFEK LAQPGEESSN VWNNAGTGHS 70 80 90 100 110 120 ALCELNYTKE GKDGTVDCSK AIKINEQYQI SKQFWAYLVK TGQLDNPDRF IQAVPHMSFV 130 140 150 160 170 180 IGEDNVAFIK SRVATLKKSV LFEKMKLSQD EEEMKSWVPL MIEGRKSDEP IALTYDETGT 190 200 210 220 230 240 DVNFGALTAK LFENLEQRGV GIQYKQNVLD IKKQKSGAWL VKVKDLETNE TTTYESDFVF 250 260 270 280 290 300 IGAGGASLPL LQKTGIKQSK HIGGFPVSGL FLRCTNQEVI DRHHAKVYGK AAVGAPPMSV 310 320 330 340 350 360 PHLDTRFVDG KRSLLFGPFA GFSPKFLKTG SHMDLIKSVK PNNIVTMLSA GIKEMSLTKY 370 380 390 400 410 420 LVSQLMLSND ERMDDLRVFF PNAKNEDWEV ITAGQRVQVI KDTEDSKGNL QFGTEVITSD 430 440 450 460 470 480 DGTLAALLGA SPGASTAVDI MFDVLQRCYR DEFKGWEPKI KEMVPSFGYR LTDHEDLYHK 490 INEEVTKYLQ VK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed: 11418146] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Shotgun proteomic analysis of total and membrane protein extracts of S. aureus strain N315." Vaezzadeh A.R., Deshusses J., Lescuye P., Hochstrasser D.F. Submitted (OCT-2007) to UniProtKB Cited for: IDENTIFICATION BY MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000018 Genomic DNA. Translation: BAB43457.1. Different initiation.
PIR	H90036.
RefSeq	NP_375478.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1125083.
GenomeReviews	Gene locus SA2155 in contig BA000018_GR.
KEGG	sau:SA2155.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P65422.
Enzyme and pathway databases
BioCyc	SAUR158879:SA2155-MON.
Family and domain databases
HAMAP	MF_00212. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MQO1_STAAN

Accession

Primary (citable) accession number: P65422
Secondary accession number(s): Q99RR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 4, 2008
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)