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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-3019-MONOMER
UniPathwayiUPA00223; UER01008

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductase (EC:1.1.5.4)
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene namesi
Name:mqo
Ordered Locus Names:BQ2027_MB2877C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001287221 – 493Probable malate:quinone oxidoreductaseAdd BLAST493

Proteomic databases

PRIDEiP65420

Structurei

3D structure databases

ProteinModelPortaliP65420
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.Curated

Phylogenomic databases

HOGENOMiHOG000109379
OMAiEPIAATK

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_00212 MQO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR006231 MQO
PfamiView protein in Pfam
PF06039 Mqo, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR01320 mal_quin_oxido, 1 hit

Sequencei

Sequence statusi: Complete.

P65420-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLARTDVV LIGAGIMSAT LGVLLRRLEP NWSITLIERL DAVAAESSGP
60 70 80 90 100
WNNAGTGHSA LCEMNYTPEM PDGSIDITKA VRVNEQFQVT RQFWAYAAEN
110 120 130 140 150
GILTDVRSFL NPVPHVSFVH GSRGVEYLRR RQKALAGNPL FAGTEFIESP
160 170 180 190 200
DEFARRLPFM AAKRAFSEPV ALNWAADGTD VDFGALAKQL IGYCVQNGTT
210 220 230 240 250
ALFGHEVRNL SRQSDGSWTV TMCNRRTGEK RKLNTKFVFV GAGGDTLPVL
260 270 280 290 300
QKSGIKEVKG FAGFPIGGRF LRAGNPALTA SHRAKVYGFP APGAPPLGAL
310 320 330 340 350
HLDLRFVNGK SWLVFGPYAG WSPKFLKHGQ ISDLPRSIRP DNLLSVLGVG
360 370 380 390 400
LTERRLLNYL ISQLRLSEPE RVSALREFAP SAIDSDWELT IAGQRVQVIR
410 420 430 440 450
RDERNGGVLE FGTTVIGDAD GSIAGLLGGS PGASTAVAIM LDVLQKCFAN
460 470 480 490
RYQSWLPTLK EMVPSLGVQL SNEPALFDEV WSWSTKALKL GAA
Length:493
Mass (Da):53,595
Last modified:October 11, 2004 - v1
Checksum:iC3B4C469FF4F285F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU01497.1
RefSeqiNP_856522.1, NC_002945.3
WP_003414545.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO44143; CDO44143; Mb2877c
PATRICifig|233413.5.peg.3155

Similar proteinsi

Entry informationi

Entry nameiMQO_MYCBO
AccessioniPrimary (citable) accession number: P65420
Secondary accession number(s): A0A1R3Y2J4, O05807, X2BM23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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