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P65419 (MQO_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable malate:quinone oxidoreductase
EC=1.1.5.4
Alternative name(s):
MQO
Malate dehydrogenase [quinone]
Gene names
Name:mqo
Ordered Locus Names:Rv2852c, MT2918
ORF Names:MTCY24A1.05
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212

Cofactor

FAD By similarity. HAMAP MF_00212

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212

Sequence similarities

Belongs to the MQO family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentplasma membrane

Inferred from direct assay. Source: MTBBASE

   Molecular functionmalate dehydrogenase (menaquinone) activity

Inferred from electronic annotation. Source: EC

malate dehydrogenase (quinone) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Probable malate:quinone oxidoreductase HAMAP MF_00212
PRO_0000128721

Sequences

Sequence LengthMass (Da)Tools
P65419 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: C3B4C469FF4F285F

FASTA49353,595
        10         20         30         40         50         60 
MSDLARTDVV LIGAGIMSAT LGVLLRRLEP NWSITLIERL DAVAAESSGP WNNAGTGHSA 

        70         80         90        100        110        120 
LCEMNYTPEM PDGSIDITKA VRVNEQFQVT RQFWAYAAEN GILTDVRSFL NPVPHVSFVH 

       130        140        150        160        170        180 
GSRGVEYLRR RQKALAGNPL FAGTEFIESP DEFARRLPFM AAKRAFSEPV ALNWAADGTD 

       190        200        210        220        230        240 
VDFGALAKQL IGYCVQNGTT ALFGHEVRNL SRQSDGSWTV TMCNRRTGEK RKLNTKFVFV 

       250        260        270        280        290        300 
GAGGDTLPVL QKSGIKEVKG FAGFPIGGRF LRAGNPALTA SHRAKVYGFP APGAPPLGAL 

       310        320        330        340        350        360 
HLDLRFVNGK SWLVFGPYAG WSPKFLKHGQ ISDLPRSIRP DNLLSVLGVG LTERRLLNYL 

       370        380        390        400        410        420 
ISQLRLSEPE RVSALREFAP SAIDSDWELT IAGQRVQVIR RDERNGGVLE FGTTVIGDAD 

       430        440        450        460        470        480 
GSIAGLLGGS PGASTAVAIM LDVLQKCFAN RYQSWLPTLK EMVPSLGVQL SNEPALFDEV 

       490 
WSWSTKALKL GAA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842581 Genomic DNA. Translation: CAB08454.1.
AE000516 Genomic DNA. Translation: AAK47244.1.
PIRG70589.
RefSeqNP_217368.1. NC_000962.2.
NP_337430.1. NC_002755.2.

3D structure databases

ProteinModelPortalP65419.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000000302; EBMYCP00000000302; EBMYCG00000000302.
EBMYCT00000070799; EBMYCP00000068858; EBMYCG00000070794.
GeneID888544.
925360.
GenomeReviewsGene locus MT2918 in contig AE000516_GR.
Gene locus Rv2852c in contig AL123456_GR.
KEGGmtc:MT2918.
mtu:Rv2852c.
PATRIC18128188. VBIMycTub22151_3193.
TIGRMT2918.

Organism-specific databases

TubercuListRv2852c.

Phylogenomic databases

GeneTreeEBGT00050000015585.
HOGENOMHBG289663.
OMAKKWVPLM.
PhylomeDBP65419.
ProtClustDBPRK05257.

Family and domain databases

HAMAPMF_00212. MQO.
[Tree]
InterProIPR006231. Malate_quinone_OxRdtase.
[Graphical view]
KOK00116.
PANTHERPTHR13847:SF14. PTHR13847:SF14. 1 hit.
PfamPF06039. Mqo. 1 hit.
[Graphical view]
TIGRFAMsTIGR01320. Mal_quin_oxido. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMQO_MYCTU
AccessionPrimary (citable) accession number: P65419
Secondary accession number(s): O05807
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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