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Protein

Molybdopterin synthase catalytic subunit

Gene

moaE

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by MoaD (By similarity).By similarity

Catalytic activityi

Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein].

Pathwayi: molybdopterin biosynthesis

This protein is involved in the pathway molybdopterin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway molybdopterin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei44SubstrateBy similarity1
Binding sitei116SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Molybdenum cofactor biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00344.

Names & Taxonomyi

Protein namesi
Recommended name:
Molybdopterin synthase catalytic subunit (EC:2.8.1.12)
Alternative name(s):
MPT synthase subunit 2
Molybdenum cofactor biosynthesis protein E
Molybdopterin-converting factor large subunit
Molybdopterin-converting factor subunit 2
Gene namesi
Name:moaE
Ordered Locus Names:SAV2271
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001630981 – 148Molybdopterin synthase catalytic subunitAdd BLAST148

Proteomic databases

PaxDbiP65400.
PRIDEiP65400.

Interactioni

Subunit structurei

Heterotetramer of 2 MoaD subunits and 2 MoaE subunits. Also stable as homodimer. The enzyme changes between these two forms during catalysis (By similarity).By similarity

Protein-protein interaction databases

STRINGi158878.SAV2271.

Structurei

3D structure databases

ProteinModelPortaliP65400.
SMRiP65400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 36Substrate bindingBy similarity3
Regioni100 – 101Substrate bindingBy similarity2
Regioni123 – 125Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the MoaE family.Curated

Phylogenomic databases

eggNOGiENOG4108ZAF. Bacteria.
COG0314. LUCA.
HOGENOMiHOG000280877.
KOiK03635.
OMAiSKDGSYW.
PhylomeDBiP65400.

Family and domain databases

CDDicd00756. MoaE. 1 hit.
Gene3Di3.90.1170.40. 1 hit.
InterProiIPR003448. Mopterin_biosynth_MoaE.
[Graphical view]
PfamiPF02391. MoaE. 1 hit.
[Graphical view]
SUPFAMiSSF54690. SSF54690. 1 hit.

Sequencei

Sequence statusi: Complete.

P65400-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKQFEIVIEP IQTEQYREFT INEYQGAVVV FTGHVREWTK GVKTEYLEYE
60 70 80 90 100
AYIPMAEKKL AQIGDEINEK WPGTITSIVH RIGPLQISDI AVLIAVSSPH
110 120 130 140
RKDAYRANEY AIERIKEIVP IWKKEIWEDG SKWQGHQKGN YEEAKREE
Length:148
Mass (Da):17,351
Last modified:October 11, 2004 - v1
Checksum:iB4293AEE3AD0C030
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58433.1.
RefSeqiWP_000808495.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58433; BAB58433; SAV2271.
KEGGisav:SAV2271.
PATRICi19565448. VBIStaAur52173_2350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58433.1.
RefSeqiWP_000808495.1. NC_002758.2.

3D structure databases

ProteinModelPortaliP65400.
SMRiP65400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2271.

Proteomic databases

PaxDbiP65400.
PRIDEiP65400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58433; BAB58433; SAV2271.
KEGGisav:SAV2271.
PATRICi19565448. VBIStaAur52173_2350.

Phylogenomic databases

eggNOGiENOG4108ZAF. Bacteria.
COG0314. LUCA.
HOGENOMiHOG000280877.
KOiK03635.
OMAiSKDGSYW.
PhylomeDBiP65400.

Enzyme and pathway databases

UniPathwayiUPA00344.

Family and domain databases

CDDicd00756. MoaE. 1 hit.
Gene3Di3.90.1170.40. 1 hit.
InterProiIPR003448. Mopterin_biosynth_MoaE.
[Graphical view]
PfamiPF02391. MoaE. 1 hit.
[Graphical view]
SUPFAMiSSF54690. SSF54690. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOAE_STAAM
AccessioniPrimary (citable) accession number: P65400
Secondary accession number(s): Q99S01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.