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Protein

Septum site-determining protein MinC

Gene

minC

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Names & Taxonomyi

Protein namesi
Recommended name:
Septum site-determining protein MinC
Gene namesi
Name:minCUniRule annotation
Ordered Locus Names:STM1814
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001890601 – 235Septum site-determining protein MinCAdd BLAST235

Proteomic databases

PaxDbiP65359.
PRIDEiP65359.

Interactioni

Subunit structurei

Interacts with MinD and FtsZ.UniRule annotation

Protein-protein interaction databases

STRINGi99287.STM1814.

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi16 – 22Combined sources7
Helixi25 – 38Combined sources14
Helixi40 – 43Combined sources4
Beta strandi47 – 54Combined sources8
Helixi61 – 69Combined sources9
Turni70 – 72Combined sources3
Beta strandi74 – 80Combined sources7
Helixi84 – 92Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GHFX-ray2.20A2-110[»]
ProteinModelPortaliP65359.
SMRiP65359.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP65359.

Family & Domainsi

Sequence similaritiesi

Belongs to the MinC family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K7U. Bacteria.
COG0850. LUCA.
HOGENOMiHOG000062060.
KOiK03610.
OMAiRIYAPNC.
PhylomeDBiP65359.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
HAMAPiMF_00267. MinC. 1 hit.
InterProiIPR016098. CAP/MinC_C.
IPR013033. MinC.
IPR007874. MinC_N.
IPR005526. Septum_form_inhib_MinC_C.
[Graphical view]
PfamiPF03775. MinC_C. 1 hit.
PF05209. MinC_N. 1 hit.
[Graphical view]
SUPFAMiSSF63848. SSF63848. 1 hit.
TIGRFAMsiTIGR01222. minC. 1 hit.

Sequencei

Sequence statusi: Complete.

P65359-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNTPIELKG SSFTLSVVHL HEAEPEVIRQ ALEDKIAQAP AFLKHAPVVI
60 70 80 90 100
NVSGLESPVN WPELHKIVTS TGLRIIGVSG CKDASLKVEI DRMGLPLLTE
110 120 130 140 150
GKEKAVRPAP VEPATPSEPP QNANPITKTR LIDVPVRSGQ RIYAPQCDLI
160 170 180 190 200
VTSHVSAGAE LIADGNIHVY GMMRGRALAG ASGDREAQIF CTHLTAELVS
210 220 230
IAGVYWLSDK IPAEFYGKAA RLRLADNALT VQPLN
Length:235
Mass (Da):25,246
Last modified:October 11, 2004 - v1
Checksum:iFF4165927F34056A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20729.1.
RefSeqiNP_460770.1. NC_003197.1.
WP_000072527.1. NC_003197.1.

Genome annotation databases

EnsemblBacteriaiAAL20729; AAL20729; STM1814.
GeneIDi1253333.
KEGGistm:STM1814.
PATRICi32382151. VBISalEnt20916_1914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006468 Genomic DNA. Translation: AAL20729.1.
RefSeqiNP_460770.1. NC_003197.1.
WP_000072527.1. NC_003197.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3GHFX-ray2.20A2-110[»]
ProteinModelPortaliP65359.
SMRiP65359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM1814.

Proteomic databases

PaxDbiP65359.
PRIDEiP65359.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL20729; AAL20729; STM1814.
GeneIDi1253333.
KEGGistm:STM1814.
PATRICi32382151. VBISalEnt20916_1914.

Phylogenomic databases

eggNOGiENOG4105K7U. Bacteria.
COG0850. LUCA.
HOGENOMiHOG000062060.
KOiK03610.
OMAiRIYAPNC.
PhylomeDBiP65359.

Miscellaneous databases

EvolutionaryTraceiP65359.

Family and domain databases

Gene3Di2.160.20.70. 1 hit.
HAMAPiMF_00267. MinC. 1 hit.
InterProiIPR016098. CAP/MinC_C.
IPR013033. MinC.
IPR007874. MinC_N.
IPR005526. Septum_form_inhib_MinC_C.
[Graphical view]
PfamiPF03775. MinC_C. 1 hit.
PF05209. MinC_N. 1 hit.
[Graphical view]
SUPFAMiSSF63848. SSF63848. 1 hit.
TIGRFAMsiTIGR01222. minC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMINC_SALTY
AccessioniPrimary (citable) accession number: P65359
Secondary accession number(s): Q8XEJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.