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P65340 (METE_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
EC=2.1.1.14
Alternative name(s):
Cobalamin-independent methionine synthase
Methionine synthase, vitamin-B12 independent isozyme
Gene names
Name:metE
Ordered Locus Names:Rv1133c, MT1165
ORF Names:MTC22G8.22
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length759 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7597595-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
PRO_0000098641

Sites

Metal binding6471Zinc By similarity
Metal binding6491Zinc By similarity
Metal binding7321Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
P65340 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 702F90BF79B25C8D

FASTA75981,582
        10         20         30         40         50         60 
MTQPVRRQPF TATITGSPRI GPRRELKRAT EGYWAGRTSR SELEAVAATL RRDTWSALAA 

        70         80         90        100        110        120 
AGLDSVPVNT FSYYDQMLDT AVLLGALPPR VSPVSDGLDR YFAAARGTDQ IAPLEMTKWF 

       130        140        150        160        170        180 
DTNYHYLVPE IGPSTTFTLH PGKVLAELKE ALGQGIPARP VIIGPITFLL LSKAVDGAGA 

       190        200        210        220        230        240 
PIERLEELVP VYSELLSLLA DGGAQWVQFD EPALVTDLSP DAPALAEAVY TALCSVSNRP 

       250        260        270        280        290        300 
AIYVATYFGD PGAALPALAR TPVEAIGVDL VAGADTSVAG VPELAGKTLV AGVVDGRNVW 

       310        320        330        340        350        360 
RTDLEAALGT LATLLGSAAT VAVSTSCSTL HVPYSLEPET DLDDALRSWL AFGAEKVREV 

       370        380        390        400        410        420 
VVLARALRDG HDAVADEIAS SRAAIASRKR DPRLHNGQIR ARIEAIVASG AHRGNAAQRR 

       430        440        450        460        470        480 
ASQDARLHLP PLPTTTIGSY PQTSAIRVAR AALRAGEIDE AEYVRRMRQE ITEVIALQER 

       490        500        510        520        530        540 
LGLDVLVHGE PERNDMVQYF AEQLAGFFAT QNGWVQSYGS RCVRPPILYG DVSRPRAMTV 

       550        560        570        580        590        600 
EWITYAQSLT DKPVKGMLTG PVTILAWSFV RDDQPLADTA NQVALAIRDE TVDLQSAGIA 

       610        620        630        640        650        660 
VIQVDEPALR ELLPLRRADQ AEYLRWAVGA FRLATSGVSD ATQIHTHLCY SEFGEVIGAI 

       670        680        690        700        710        720 
ADLDADVTSI EAARSHMEVL DDLNAIGFAN GVGPGVYDIH SPRVPSAEEM ADSLRAALRA 

       730        740        750 
VPAERLWVNP DCGLKTRNVD EVTASLHNMV AAAREVRAG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842575 Genomic DNA. Translation: CAB09044.1.
AE000516 Genomic DNA. Translation: AAK45422.1.
PIRF70539.
RefSeqNP_215649.1. NC_000962.2.
NP_335608.1. NC_002755.2.

3D structure databases

ProteinModelPortalP65340.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000001734; EBMYCP00000001734; EBMYCG00000001733.
EBMYCT00000072486; EBMYCP00000070545; EBMYCG00000072481.
GeneID888947.
924927.
GenomeReviewsGene locus MT1165 in contig AE000516_GR.
Gene locus Rv1133c in contig AL123456_GR.
KEGGmtc:MT1165.
mtu:Rv1133c.
PATRIC18124325. VBIMycTub22151_1282.
TIGRMT1165.

Organism-specific databases

TubercuListRv1133c.

Phylogenomic databases

GeneTreeEBGT00050000017657.
HOGENOMHBG287495.
OMARNIWRAN.
PhylomeDBP65340.
ProtClustDBPRK05222.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMETE_MYCTU
AccessionPrimary (citable) accession number: P65340
Secondary accession number(s): O06584
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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