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Protein

S-ribosylhomocysteine lyase

Gene

luxS

Organism
Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD).UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Fe cationUniRule annotationNote: Binds 1 Fe cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57IronUniRule annotation1
Metal bindingi61IronUniRule annotation1
Metal bindingi127IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAutoinducer synthesis, Quorum sensing
LigandIron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyaseUniRule annotation (EC:4.4.1.21UniRule annotation)
Alternative name(s):
AI-2 synthesis proteinUniRule annotation
Autoinducer-2 production protein LuxSUniRule annotation
Gene namesi
Name:luxSUniRule annotation
Ordered Locus Names:SAG0305
OrganismiStreptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)
Taxonomic identifieri208435 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000821 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001722621 – 160S-ribosylhomocysteine lyaseAdd BLAST160

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliP65333.
SMRiP65333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040372.
KOiK07173.
OMAiAIHTLEH.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS. 1 hit.
InterProiView protein in InterPro
IPR037005. LuxS_sf.
IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
PfamiView protein in Pfam
PF02664. LuxS. 1 hit.
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013172. S-ribosylhomocysteinase. 1 hit.
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

P65333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKEVVVESF ELDHTIVKAP YVRLISEEVG PVGDIITNFD IRLIQPNENA
60 70 80 90 100
IDTAGLHTIE HLLAKLIRQR INGLIDCSPF GCRTGFHMIM WGKQDATEIA
110 120 130 140 150
KVIKSSLEAI AGGVTWEDVP GTTIESCGNY KDHSLHSAQE WAKLILSQGI
160
SDNAFERHIV
Length:160
Mass (Da):17,736
Last modified:October 11, 2004 - v1
Checksum:iF660D88A213D31BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009948 Genomic DNA. Translation: AAM99212.1.
RefSeqiNP_687340.1. NC_004116.1.
WP_000159885.1. NC_004116.1.

Genome annotation databases

EnsemblBacteriaiAAM99212; AAM99212; SAG0305.
GeneIDi1013094.
KEGGisag:SAG0305.
PATRICifig|208435.3.peg.302.

Similar proteinsi

Entry informationi

Entry nameiLUXS_STRA5
AccessioniPrimary (citable) accession number: P65333
Secondary accession number(s): Q8E1P8, Q8E763
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families