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Protein

Riboflavin synthase

Gene

ribE

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.By similarity

Catalytic activityi

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathwayi: riboflavin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 6,7-dimethyl-8-ribityllumazine synthase (ribH)
  2. Riboflavin synthase (ribE)
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136Lumazine 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processRiboflavin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00275; UER00405.

Names & Taxonomyi

Protein namesi
Recommended name:
Riboflavin synthase (EC:2.5.1.9)
Short name:
RS
Gene namesi
Name:ribE
Synonyms:ribC
Ordered Locus Names:BQ2027_MB1447
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000681691 – 201Riboflavin synthaseAdd BLAST201

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP65328.
SMRiP65328.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 97Lumazine-binding 1Add BLAST97
Repeati98 – 197Lumazine-binding 2Add BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 6Lumazine 1 bindingBy similarity3
Regioni47 – 49Lumazine 2 binding; shared with one trimeric partnerBy similarity3
Regioni62 – 67Lumazine 2 binding; shared with one trimeric partnerBy similarity6
Regioni101 – 103Lumazine 2 binding; shared with one trimeric partnerBy similarity3
Regioni145 – 147Lumazine 1 bindingBy similarity3
Regioni162 – 167Lumazine 1 bindingBy similarity6

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000151758.
KOiK00793.
OMAiHFVTGHV.

Family and domain databases

CDDicd00402. Riboflavin_synthase_like. 1 hit.
Gene3Di2.40.30.20. 2 hits.
InterProiView protein in InterPro
IPR023366. ATP_synth_asu-like.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
PANTHERiPTHR21098. PTHR21098. 1 hit.
PfamiView protein in Pfam
PF00677. Lum_binding. 2 hits.
PIRSFiPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMiSSF63380. SSF63380. 2 hits.
TIGRFAMsiTIGR00187. ribE. 1 hit.
PROSITEiView protein in PROSITE
PS51177. LUMAZINE_BIND. 2 hits.

Sequencei

Sequence statusi: Complete.

P65328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTGIVEERG EVTGREALVD AARLTIRGPM VTADAGHGDS IAVNGVCLTV
60 70 80 90 100
VDVLPDGQFT ADVMAETLNR SNLGELRPGS RVNLERAAAL GSRLGGHIVQ
110 120 130 140 150
GHVDATGEIV ARCPSEHWEV VRIEMPASVA RYVVEKGSIT VDGISLTVSG
160 170 180 190 200
LGAEQRDWFE VSLIPTTREL TTLGSAAVGT RVNLEVDVVA KYVERLMRSA

G
Length:201
Mass (Da):21,320
Last modified:October 11, 2004 - v1
Checksum:i1CE1C3A20A61D2FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA. Translation: SIU00050.1.
RefSeqiNP_855099.1. NC_002945.3.
WP_003407318.1. NC_002945.4.

Genome annotation databases

EnsemblBacteriaiCDO42695; CDO42695; Mb1447.
KEGGimbo:Mb1447.
PATRICifig|233413.5.peg.1582.

Similar proteinsi

Entry informationi

Entry nameiRISA_MYCBO
AccessioniPrimary (citable) accession number: P65328
Secondary accession number(s): A0A1R3XYA8, P71680, X2BI92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 27, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways