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P65327 (RISA_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Riboflavin synthase
Short name=RS
EC=2.5.1.9
Gene names
Name:ribE
Synonyms:ribC
Ordered Locus Names:Rv1412, MT1456
ORF Names:MTCY21B4.29
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil By similarity.

Catalytic activity

2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.

Subunit structure

Homotrimer By similarity.

Sequence similarities

Contains 2 lumazine-binding repeats.

Ontologies

Keywords
   Biological processRiboflavin biosynthesis
   DomainRepeat
   Molecular functionTransferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processriboflavin biosynthetic process

Inferred from direct assay PubMed 19545132. Source: MTBBASE

   Molecular_functionoxidoreductase activity

Inferred from electronic annotation. Source: InterPro

riboflavin synthase activity

Inferred from direct assay PubMed 19545132. Source: MTBBASE

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 201201Riboflavin synthase
PRO_0000068168

Regions

Repeat1 – 9797Lumazine-binding 1
Repeat98 – 197100Lumazine-binding 2
Region4 – 63Substrate binding By similarity
Region47 – 493Substrate binding By similarity
Region62 – 676Substrate binding By similarity

Sequences

Sequence LengthMass (Da)Tools
P65327 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 1CE1C3A20A61D2FF

FASTA20121,320
        10         20         30         40         50         60 
MFTGIVEERG EVTGREALVD AARLTIRGPM VTADAGHGDS IAVNGVCLTV VDVLPDGQFT 

        70         80         90        100        110        120 
ADVMAETLNR SNLGELRPGS RVNLERAAAL GSRLGGHIVQ GHVDATGEIV ARCPSEHWEV 

       130        140        150        160        170        180 
VRIEMPASVA RYVVEKGSIT VDGISLTVSG LGAEQRDWFE VSLIPTTREL TTLGSAAVGT 

       190        200 
RVNLEVDVVA KYVERLMRSA G

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842576 Genomic DNA. Translation: CAB02162.1.
AE000516 Genomic DNA. Translation: AAK45721.1.
AL123456 Genomic DNA. Translation: CCP44171.1.
PIRA70902.
RefSeqNP_215928.1. NC_000962.3.
NP_335907.1. NC_002755.2.
YP_006514792.1. NC_018143.1.

3D structure databases

ProteinModelPortalP65327.
SMRP65327. Positions 1-199.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv1412.

Proteomic databases

PRIDEP65327.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK45721; AAK45721; MT1456.
GeneID13320001.
886690.
924516.
KEGGmtc:MT1456.
mtu:Rv1412.
mtv:RVBD_1412.
PATRIC18124970. VBIMycTub22151_1599.

Organism-specific databases

TubercuListRv1412.

Phylogenomic databases

eggNOGCOG0307.
HOGENOMHOG000151758.
KOK00793.
OMASRYVVEK.
ProtClustDBPRK09289.

Enzyme and pathway databases

UniPathwayUPA00275; UER00405.

Family and domain databases

Gene3D2.40.30.20. 2 hits.
InterProIPR023366. ATPase_F1/A1-cplx_a_su_N.
IPR001783. Lumazine-bd.
IPR026017. Lumazine-bd_dom.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PANTHERPTHR21098. PTHR21098. 1 hit.
PfamPF00677. Lum_binding. 2 hits.
[Graphical view]
PIRSFPIRSF000498. Riboflavin_syn_A. 1 hit.
SUPFAMSSF63380. Riboflavin_synthase_like_b-brl. 2 hits.
TIGRFAMsTIGR00187. ribE. 1 hit.
PROSITEPS51177. LUMAZINE_BIND. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRISA_MYCTU
AccessionPrimary (citable) accession number: P65327
Secondary accession number(s): L0T6K5, P71680
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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