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P65325

- LPXK_BRUME

UniProt

P65325 - LPXK_BRUME

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Protein

Tetraacyldisaccharide 4'-kinase

Gene

lpxK

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).UniRule annotation

Catalytic activityi

ATP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate).UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 618ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tetraacyldisaccharide 4'-kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00359; UER00482.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraacyldisaccharide 4'-kinaseUniRule annotation (EC:2.7.1.130UniRule annotation)
Alternative name(s):
Lipid A 4'-kinaseUniRule annotation
Gene namesi
Name:lpxKUniRule annotation
Ordered Locus Names:BMEII1028
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Tetraacyldisaccharide 4'-kinasePRO_0000190914Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEII1028.

Structurei

3D structure databases

ProteinModelPortaliP65325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxK family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004954.
KOiK00912.
OMAiPKRADAV.
OrthoDBiEOG60GRWT.

Family and domain databases

HAMAPiMF_00409. LpxK.
InterProiIPR027417. P-loop_NTPase.
IPR003758. Tetraacyldisaccharide_4-kinase.
[Graphical view]
PfamiPF02606. LpxK. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00682. lpxK. 1 hit.

Sequencei

Sequence statusi: Complete.

P65325-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASEAPPFWW DEPDWRALAL APAAWIYGRV SGRRLIRAVP PRVSLPVLCV
60 70 80 90 100
GNFTVGGAGK TPTAIAFARG AIARGMKPGI VSRGYGGNYS GLHLVDPGHD
110 120 130 140 150
GARHVGDEPL LLARHAAVAL SPDRVKAAEY LKSLGCDFII MDDGFQSARL
160 170 180 190 200
HADFSLLVVD ASRGIGNGRV IPAGPLRAPL TDQMRKTDAL LCIGKGNGAD
210 220 230 240 250
FVIRQAARAG RPIYHAQLRP SSSATVAGRR WLAFAGIGNP DKFYESVRQA
260 270 280 290 300
GGEVVETHSF ADHYSFEPDD IRGLVDMARR QGLGLITTAK DHVRLATMPG
310 320 330 340
VPPEFLSKLA VLDVDLEFDR TDALDHILDT VVERFKSRLH G
Length:341
Mass (Da):36,782
Last modified:October 11, 2004 - v1
Checksum:i93014F0F6B7C3DCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL54270.1.
PIRiAC3638.
RefSeqiNP_542006.1. NC_003318.1.

Genome annotation databases

EnsemblBacteriaiAAL54270; AAL54270; BMEII1028.
GeneIDi1198800.
KEGGibme:BMEII1028.
PATRICi17798931. VBIBruMel146950_1809.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL54270.1 .
PIRi AC3638.
RefSeqi NP_542006.1. NC_003318.1.

3D structure databases

ProteinModelPortali P65325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEII1028.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL54270 ; AAL54270 ; BMEII1028 .
GeneIDi 1198800.
KEGGi bme:BMEII1028.
PATRICi 17798931. VBIBruMel146950_1809.

Phylogenomic databases

HOGENOMi HOG000004954.
KOi K00912.
OMAi PKRADAV.
OrthoDBi EOG60GRWT.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00482 .

Family and domain databases

HAMAPi MF_00409. LpxK.
InterProi IPR027417. P-loop_NTPase.
IPR003758. Tetraacyldisaccharide_4-kinase.
[Graphical view ]
Pfami PF02606. LpxK. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00682. lpxK. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiLPXK_BRUME
AccessioniPrimary (citable) accession number: P65325
Secondary accession number(s): Q8YB72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3