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P65325

- LPXK_BRUME

UniProt

P65325 - LPXK_BRUME

Protein

Tetraacyldisaccharide 4'-kinase

Gene

lpxK

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).UniRule annotation

    Catalytic activityi

    ATP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis(3-hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate).UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi54 – 618ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tetraacyldisaccharide 4'-kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00359; UER00482.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tetraacyldisaccharide 4'-kinaseUniRule annotation (EC:2.7.1.130UniRule annotation)
    Alternative name(s):
    Lipid A 4'-kinaseUniRule annotation
    Gene namesi
    Name:lpxKUniRule annotation
    Ordered Locus Names:BMEII1028
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Tetraacyldisaccharide 4'-kinasePRO_0000190914Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEII1028.

    Structurei

    3D structure databases

    ProteinModelPortaliP65325.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxK family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000004954.
    KOiK00912.
    OMAiPKRADAV.
    OrthoDBiEOG60GRWT.

    Family and domain databases

    HAMAPiMF_00409. LpxK.
    InterProiIPR027417. P-loop_NTPase.
    IPR003758. Tetraacyldisaccharide_4-kinase.
    [Graphical view]
    PfamiPF02606. LpxK. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00682. lpxK. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P65325-1 [UniParc]FASTAAdd to Basket

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    MASEAPPFWW DEPDWRALAL APAAWIYGRV SGRRLIRAVP PRVSLPVLCV    50
    GNFTVGGAGK TPTAIAFARG AIARGMKPGI VSRGYGGNYS GLHLVDPGHD 100
    GARHVGDEPL LLARHAAVAL SPDRVKAAEY LKSLGCDFII MDDGFQSARL 150
    HADFSLLVVD ASRGIGNGRV IPAGPLRAPL TDQMRKTDAL LCIGKGNGAD 200
    FVIRQAARAG RPIYHAQLRP SSSATVAGRR WLAFAGIGNP DKFYESVRQA 250
    GGEVVETHSF ADHYSFEPDD IRGLVDMARR QGLGLITTAK DHVRLATMPG 300
    VPPEFLSKLA VLDVDLEFDR TDALDHILDT VVERFKSRLH G 341
    Length:341
    Mass (Da):36,782
    Last modified:October 11, 2004 - v1
    Checksum:i93014F0F6B7C3DCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008918 Genomic DNA. Translation: AAL54270.1.
    PIRiAC3638.
    RefSeqiNP_542006.1. NC_003318.1.

    Genome annotation databases

    EnsemblBacteriaiAAL54270; AAL54270; BMEII1028.
    GeneIDi1198800.
    KEGGibme:BMEII1028.
    PATRICi17798931. VBIBruMel146950_1809.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008918 Genomic DNA. Translation: AAL54270.1 .
    PIRi AC3638.
    RefSeqi NP_542006.1. NC_003318.1.

    3D structure databases

    ProteinModelPortali P65325.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEII1028.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL54270 ; AAL54270 ; BMEII1028 .
    GeneIDi 1198800.
    KEGGi bme:BMEII1028.
    PATRICi 17798931. VBIBruMel146950_1809.

    Phylogenomic databases

    HOGENOMi HOG000004954.
    KOi K00912.
    OMAi PKRADAV.
    OrthoDBi EOG60GRWT.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00482 .

    Family and domain databases

    HAMAPi MF_00409. LpxK.
    InterProi IPR027417. P-loop_NTPase.
    IPR003758. Tetraacyldisaccharide_4-kinase.
    [Graphical view ]
    Pfami PF02606. LpxK. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00682. lpxK. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiLPXK_BRUME
    AccessioniPrimary (citable) accession number: P65325
    Secondary accession number(s): Q8YB72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3