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Protein

Galactose-6-phosphate isomerase subunit LacA

Gene

lacA

Organism
Staphylococcus aureus (strain MW2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-galactose 6-phosphate = D-tagatose 6-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. galactose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. galactose catabolic process Source: UniProtKB-UniPathway
  2. lactose catabolic process via tagatose-6-phosphate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lactose metabolism

Enzyme and pathway databases

BioCyciSAUR196620:GJ9Z-2199-MONOMER.
UniPathwayiUPA00702; UER00714.

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-6-phosphate isomerase subunit LacAUniRule annotation (EC:5.3.1.26UniRule annotation)
Gene namesi
Name:lacAUniRule annotation
Ordered Locus Names:MW2121
OrganismiStaphylococcus aureus (strain MW2)
Taxonomic identifieri196620 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000418 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 142142Galactose-6-phosphate isomerase subunit LacAPRO_0000208110Add
BLAST

Interactioni

Subunit structurei

Heteromultimeric protein consisting of LacA and LacB.UniRule annotation

Protein-protein interaction databases

STRINGi196620.MW2121.

Structurei

3D structure databases

ProteinModelPortaliP65252.
SMRiP65252. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LacAB/RpiB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0698.
HOGENOMiHOG000226301.
KOiK01819.
OMAiRMITVGA.
OrthoDBiEOG6X9MQG.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01555. LacA.
InterProiIPR004783. LacA.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01118. lacA. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.

Sequencei

Sequence statusi: Complete.

P65252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIIIGSDEA GKRLKEVIKS YLLDNKYDVV DVTEGQEVDF VDATLAVAKD
60 70 80 90 100
VQSQEGNLGI VIDAFGAGSF MVATKIKGMI AAEVSDERSG YMTRGHNNSR
110 120 130 140
MITMGSEIVG DTLAKNVVKG FVEGKYDGGR HQIRVDMLNK MC
Length:142
Mass (Da):15,395
Last modified:October 10, 2004 - v1
Checksum:iA52C4A7DBF30BE19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95986.1.
RefSeqiNP_646938.1. NC_003923.1.

Genome annotation databases

EnsemblBacteriaiBAB95986; BAB95986; BAB95986.
KEGGisam:MW2121.
PATRICi19570968. VBIStaAur44266_2193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000033 Genomic DNA. Translation: BAB95986.1.
RefSeqiNP_646938.1. NC_003923.1.

3D structure databases

ProteinModelPortaliP65252.
SMRiP65252. Positions 1-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi196620.MW2121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB95986; BAB95986; BAB95986.
KEGGisam:MW2121.
PATRICi19570968. VBIStaAur44266_2193.

Phylogenomic databases

eggNOGiCOG0698.
HOGENOMiHOG000226301.
KOiK01819.
OMAiRMITVGA.
OrthoDBiEOG6X9MQG.

Enzyme and pathway databases

UniPathwayiUPA00702; UER00714.
BioCyciSAUR196620:GJ9Z-2199-MONOMER.

Family and domain databases

Gene3Di3.40.1400.10. 1 hit.
HAMAPiMF_01555. LacA.
InterProiIPR004783. LacA.
IPR003500. RpiB_LacA_LacB.
[Graphical view]
PANTHERiPTHR30345. PTHR30345. 1 hit.
PfamiPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFiPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMiSSF89623. SSF89623. 1 hit.
TIGRFAMsiTIGR01118. lacA. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MW2.

Entry informationi

Entry nameiLACA_STAAW
AccessioniPrimary (citable) accession number: P65252
Secondary accession number(s): Q99S74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2004
Last sequence update: October 10, 2004
Last modified: March 31, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.