P65251 (LACA_STAAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-6-phosphate isomerase subunit LacA
EC=5.3.1.26

Gene names

Name:	lacA
Ordered Locus Names:	SA1997

Organism

Staphylococcus aureus (strain N315) [Complete proteome] [HAMAP]

Taxonomic identifier

158879 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-galactose 6-phosphate = D-tagatose 6-phosphate. HAMAP-Rule MF_01555
Pathway	Carbohydrate metabolism; D-galactose 6-phosphate degradation; D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1. HAMAP-Rule MF_01555
Subunit structure	Heteromultimeric protein consisting of LacA and LacB By similarity.
Sequence similarities	Belongs to the LacAB/RpiB family.

Ontologies

Keywords
Biological process	Lactose metabolism
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	galactose catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway lactose catabolic process via tagatose-6-phosphate Inferred from electronic annotation. Source: HAMAP
Molecular_function	galactose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Galactose-6-phosphate isomerase subunit LacA HAMAP-Rule MF_01555		PRO_0000208111

Sequences

	Sequence		Length	Mass (Da)
	P65251 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: A52C4A7DBF30BE19	FASTA	142	15,395
	10 20 30 40 50 60 MAIIIGSDEA GKRLKEVIKS YLLDNKYDVV DVTEGQEVDF VDATLAVAKD VQSQEGNLGI 70 80 90 100 110 120 VIDAFGAGSF MVATKIKGMI AAEVSDERSG YMTRGHNNSR MITMGSEIVG DTLAKNVVKG 130 140 FVEGKYDGGR HQIRVDMLNK MC

References

[1]

"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet 357:1225-1240(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: N315.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000018 Genomic DNA. Translation: BAB43287.1.
PIR	F90015.
RefSeq	NP_375308.1. NC_002745.2.
3D structure databases
ProteinModelPortal	P65251.
SMR	P65251. Positions 1-141.
ModBase	Search...
Protein-protein interaction databases
STRING	158879.SA1997.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB43287; BAB43287; BAB43287.
GeneID	1124913.
KEGG	sau:SA1997.
PATRIC	19576480. VBIStaAur116463_2158.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0698.
HOGENOM	HOG000226301.
KO	K01819.
OMA	HEVQKND.
ProtClustDB	PRK08621.
Enzyme and pathway databases
BioCyc	SAUR158879:GJCB-2145-MONOMER.
UniPathway	UPA00702; UER00714.
Family and domain databases
Gene3D	3.40.1400.10. 1 hit.
HAMAP	MF_01555. LacA.
InterPro	IPR004783. Gal-6-P_isomerase_su_LacA. IPR003500. Rib/Gal_isomrase. [Graphical view]
PANTHER	PTHR30345. PTHR30345. 1 hit.
Pfam	PF02502. LacAB_rpiB. 1 hit. [Graphical view]
PIRSF	PIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAM	SSF89623. Rib/Gal_isomrase. 1 hit.
TIGRFAMs	TIGR01118. lacA. 1 hit. TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LACA_STAAN

Accession

Primary (citable) accession number: P65251
Secondary accession number(s): Q99S74

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program