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Protein

Thymidylate kinase

Gene

tmk

Organism
Staphylococcus aureus (strain N315)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:SA0440
OrganismiStaphylococcus aureus (strain N315)
Taxonomic identifieri158879 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000751 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001553401 – 205Thymidylate kinaseAdd BLAST205

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi15 – 26Combined sources12
Turni27 – 29Combined sources3
Beta strandi32 – 38Combined sources7
Helixi42 – 52Combined sources11
Helixi59 – 76Combined sources18
Helixi78 – 83Combined sources6
Beta strandi87 – 92Combined sources6
Helixi94 – 100Combined sources7
Turni101 – 105Combined sources5
Helixi109 – 120Combined sources12
Beta strandi126 – 132Combined sources7
Helixi135 – 144Combined sources10
Helixi154 – 173Combined sources20
Beta strandi176 – 182Combined sources7
Helixi187 – 202Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HDCX-ray2.05A/B1-205[»]
4HEJX-ray2.00A/B1-205[»]
ProteinModelPortaliP65249
SMRiP65249
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229078
KOiK00943
OMAiFLYTADH

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit
PROSITEiView protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P65249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFITFEGP EGSGKTTVIN EVYHRLVKDY DVIMTREPGG VPTGEEIRKI
60 70 80 90 100
VLEGNDMDIR TEAMLFAASR REHLVLKVIP ALKEGKVVLC DRYIDSSLAY
110 120 130 140 150
QGYARGIGVE EVRALNEFAI NGLYPDLTIY LNVSAEVGRE RIIKNSRDQN
160 170 180 190 200
RLDQEDLKFH EKVIEGYQEI IHNESQRFKS VNADQPLENV VEDTYQTIIK

YLEKI
Length:205
Mass (Da):23,425
Last modified:October 11, 2004 - v1
Checksum:i71F9C96511FF3A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000018 Genomic DNA Translation: BAB41670.1
PIRiC89814
RefSeqiWP_001272126.1, NC_002745.2

Genome annotation databases

EnsemblBacteriaiBAB41670; BAB41670; BAB41670
KEGGisau:SA0440

Similar proteinsi

Entry informationi

Entry nameiKTHY_STAAN
AccessioniPrimary (citable) accession number: P65249
Secondary accession number(s): Q99WC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

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