Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thymidylate kinase

Gene

tmk

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:SAV0482
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001553391 – 205Thymidylate kinaseAdd BLAST205

Proteomic databases

PaxDbiP65248

Interactioni

Protein-protein interaction databases

STRINGi158878.SAV0482

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi15 – 26Combined sources12
Turni27 – 29Combined sources3
Beta strandi32 – 35Combined sources4
Turni37 – 40Combined sources4
Helixi42 – 53Combined sources12
Helixi59 – 76Combined sources18
Helixi78 – 83Combined sources6
Beta strandi87 – 92Combined sources6
Helixi94 – 100Combined sources7
Turni101 – 105Combined sources5
Helixi109 – 120Combined sources12
Beta strandi126 – 132Combined sources7
Helixi135 – 145Combined sources11
Beta strandi146 – 148Combined sources3
Helixi154 – 171Combined sources18
Turni175 – 177Combined sources3
Beta strandi178 – 182Combined sources5
Helixi187 – 203Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CCGX-ray2.30A/B1-205[»]
2CCJX-ray1.70A/B1-205[»]
2CCKX-ray2.21A/B1-205[»]
4DWJX-ray2.74A/B/C/D/E/F/G/H1-205[»]
4EAQX-ray1.85A/B1-205[»]
4F4IX-ray2.45A/B1-205[»]
4GFDX-ray1.80A/B1-205[»]
4MQBX-ray1.55A/B1-205[»]
ProteinModelPortaliP65248
SMRiP65248
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP65248

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD Bacteria
COG0125 LUCA
HOGENOMiHOG000229078
KOiK00943
OMAiFLYTADH
PhylomeDBiP65248

Family and domain databases

HAMAPiMF_00165 Thymidylate_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR018095 Thymidylate_kin_CS
IPR018094 Thymidylate_kinase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00041 DTMP_kinase, 1 hit
PROSITEiView protein in PROSITE
PS01331 THYMIDYLATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P65248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFITFEGP EGSGKTTVIN EVYHRLVKDY DVIMTREPGG VPTGEEIRKI
60 70 80 90 100
VLEGNDMDIR TEAMLFAASR REHLVLKVIP ALKEGKVVLC DRYIDSSLAY
110 120 130 140 150
QGYARGIGVE EVRALNEFAI NGLYPDLTIY LNVSAEVGRE RIIKNSRDQN
160 170 180 190 200
RLDQEDLKFH EKVIEGYQEI IHNESQRFKS VNADQPLENV VEDTYQTIIK

YLEKI
Length:205
Mass (Da):23,425
Last modified:October 11, 2004 - v1
Checksum:i71F9C96511FF3A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB56644.1
RefSeqiWP_001272126.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB56644; BAB56644; SAV0482
KEGGisav:SAV0482

Similar proteinsi

Entry informationi

Entry nameiKTHY_STAAM
AccessioniPrimary (citable) accession number: P65248
Secondary accession number(s): Q99WC1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health