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P65219

- KGUA_STAAM

UniProt

P65219 - KGUA_STAAM

Protein

Guanylate kinase

Gene

gmk

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (11 Oct 2004)
      Previous versions | rss
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    Functioni

    Essential for recycling GMP and indirectly, cGMP.UniRule annotation

    Catalytic activityi

    ATP + GMP = ADP + GDP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 208ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. guanylate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAUR158878:GJJ5-1227-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
    Alternative name(s):
    GMP kinaseUniRule annotation
    Gene namesi
    Name:gmkUniRule annotation
    Ordered Locus Names:SAV1209
    OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
    Taxonomic identifieri158878 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000002481: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 207207Guanylate kinasePRO_0000170604Add
    BLAST

    Proteomic databases

    PRIDEiP65219.

    2D gel databases

    World-2DPAGE0002:P65219.

    Interactioni

    Protein-protein interaction databases

    STRINGi158878.SAV1209.

    Structurei

    3D structure databases

    ProteinModelPortaliP65219.
    SMRiP65219. Positions 5-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 185180Guanylate kinase-likeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the guanylate kinase family.UniRule annotation
    Contains 1 guanylate kinase-like domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0194.
    HOGENOMiHOG000037639.
    KOiK00942.
    OMAiVELACDR.
    OrthoDBiEOG6CP410.
    PhylomeDBiP65219.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00328. Guanylate_kinase.
    InterProiIPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00625. Guanylate_kin. 1 hit.
    [Graphical view]
    SMARTiSM00072. GuKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P65219-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNEKGLLIV LSGPSGVGKG TVRKRIFEDP STSYKYSISM TTRQMREGEV    50
    DGVDYFFKTR DAFEALIKDD QFIEYAEYVG NYYGTPVQYV KDTMDEGHDV 100
    FLEIEVEGAK QVRKKFPDAL FIFLAPPSLD HLRERLVGRG TESNEKIQSR 150
    INEARKEVEM MNLYDYVVVN DEVELAKNRI QCIVEAEHLK RERVEAKYRK 200
    MILEAKK 207
    Length:207
    Mass (Da):24,022
    Last modified:October 11, 2004 - v1
    Checksum:iFE433434A722C98F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB57371.1.
    RefSeqiNP_371733.1. NC_002758.2.

    Genome annotation databases

    EnsemblBacteriaiBAB57371; BAB57371; SAV1209.
    GeneIDi1121186.
    KEGGisav:SAV1209.
    PATRICi19563131. VBIStaAur52173_1243.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000017 Genomic DNA. Translation: BAB57371.1 .
    RefSeqi NP_371733.1. NC_002758.2.

    3D structure databases

    ProteinModelPortali P65219.
    SMRi P65219. Positions 5-197.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 158878.SAV1209.

    2D gel databases

    World-2DPAGE 0002:P65219.

    Proteomic databases

    PRIDEi P65219.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB57371 ; BAB57371 ; SAV1209 .
    GeneIDi 1121186.
    KEGGi sav:SAV1209.
    PATRICi 19563131. VBIStaAur52173_1243.

    Phylogenomic databases

    eggNOGi COG0194.
    HOGENOMi HOG000037639.
    KOi K00942.
    OMAi VELACDR.
    OrthoDBi EOG6CP410.
    PhylomeDBi P65219.

    Enzyme and pathway databases

    BioCyci SAUR158878:GJJ5-1227-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00328. Guanylate_kinase.
    InterProi IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR017665. Guanylate_kinase.
    IPR020590. Guanylate_kinase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00625. Guanylate_kin. 1 hit.
    [Graphical view ]
    SMARTi SM00072. GuKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Mu50 / ATCC 700699.

    Entry informationi

    Entry nameiKGUA_STAAM
    AccessioniPrimary (citable) accession number: P65219
    Secondary accession number(s): Q99UQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 11, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3