Reviewed, UniProtKB/Swiss-Prot P65166 (SUHB_MYCBO)

Names and origin

Protein names

Recommended name:
    Inositol-1-monophosphatase
      Short name=IMPase
      Short name=Inositol-1-phosphatase
      Short name=I-1-Pase
    EC=3.1.3.25

Gene names

Name:	suhB
Ordered Locus Names:	Mb2720c

Organism

Mycobacterium bovis [Complete proteome] [HAMAP]

Taxonomic identifier

1765 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Myo-inositol phosphate + H2O = myo-inositol + phosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the inositol monophosphatase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	inositol-1(or 4)-monophosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Inositol-1-monophosphatase		PRO_0000142565
Regions
	Region	106 – 109	4	Substrate binding By similarity
Sites
	Metal binding	83	1	Magnesium 1 By similarity
	Metal binding	104	1	Magnesium 1 By similarity
	Metal binding	104	1	Magnesium 2 By similarity
	Metal binding	106	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	107	1	Magnesium 2 By similarity
	Metal binding	235	1	Magnesium 2 By similarity
	Binding site	83	1	Substrate By similarity
	Binding site	206	1	Substrate By similarity
	Binding site	235	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P65166-1 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 2C8A3F9A15D515CE	FASTA	290	30,027
	10 20 30 40 50 60 MTRPDNEPAR LRSVAENLAA EAAAFVRGRR AEVFGISRAG DGDGAVRAKS SPTDPVTVVD 70 80 90 100 110 120 TDTERLLRDR LAQLRPGDPI LGEEGGGPAD VTATPSDRVT WVLDPIDGTV NFVYGIPAYA 130 140 150 160 170 180 VSIGAQVGGI TVAGAVADVA ARTVYSAATG LGAHLTDERG RHVLRCTGVD ELSMALLGTG 190 200 210 220 230 240 FGYSVRCREK QAELLAHVVP LVRDVRRIGS AALDLCMVAA GRLDAYYEHG VQVWDCAAGA 250 260 270 280 290 LIAAEAGARV LLSTPRAGGA GLVVVAAAPG IADELLAALQ RFNGLEPIPD

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed: 12788972] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BX248343 Genomic DNA. Translation: CAD94905.1.
RefSeq	NP_856366.1.
3D structure databases
HSSP	HSSP built from PDB template 1IMD based on UniProtKB P29218.
ModBase	Search...
Genome annotation databases
GeneID	1091891.
GenomeReviews	Gene locus Mb2720c in contig BX248333_GR.
KEGG	mbo:Mb2720c.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	P65166.
OMA	GFGGPWD.
Enzyme and pathway databases
BRENDA	3.1.3.25. 3091.
Family and domain databases
InterPro	IPR020583. Inositol_monoP_metal-BS. IPR000760. Inositol_monophosphatase. IPR020550. Inositol_monophosphatase_CS. [Graphical view]
PANTHER	PTHR20854. Inositol_P. 1 hit.
Pfam	PF00459. Inositol_P. 1 hit. [Graphical view]
PRINTS	PR00377. IMPHPHTASES.
ProDom	PD023420. Inositol_P. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00629. IMP_1. 1 hit. PS00630. IMP_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUHB_MYCBO

Accession

Primary (citable) accession number: P65166
Secondary accession number(s): O07203

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)