P65162 (ILVH_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetolactate synthase small subunit
EC=2.2.1.6

Alternative name(s):
Acetohydroxy-acid synthase small subunit
Short name=AHAS
Short name=ALS

Gene names

Name:	ilvH
Synonyms:	ilvN
Ordered Locus Names:	Mb3027c

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]

Taxonomic identifier

233413 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium bovis

Protein attributes

Sequence length	168 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 pyruvate = 2-acetolactate + CO2.
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.
Subunit structure	Dimer of large and small chains By similarity.
Sequence similarities	Belongs to the acetolactate synthase small subunit family. Contains 1 ACT domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway valine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	acetolactate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 168	168	Acetolactate synthase small subunit		PRO_0000151417
Regions
	Domain	6 – 79	74	ACT

Sequences

	Sequence		Length	Mass (Da)
	P65162 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 523488D6114AB354	FASTA	168	18,187
	10 20 30 40 50 60 MSPKTHTLSV LVEDKPGVLA RVAALFSRRG FNIESLAVGA TECKDRSRMT IVVSAEDTPL 70 80 90 100 110 120 EQITKQLNKL INVIKIVEQD DEHSVSRELA LIKVQADAGS RSQVIEAVNL FRANVIDVSP 130 140 150 160 ESLTVEATGN RGKLEALLRV LEPFGIREIA QSGMVSLSRG PRGIGTAK

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248344 Genomic DNA. Translation: CAD96714.1.
RefSeq	NP_856672.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P65162.
SMR	P65162. Positions 6-162.
ModBase	Search...
Protein-protein interaction databases
STRING	233413.Mb3027c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD96714; CAD96714; Mb3027c.
GeneID	1093699.
KEGG	mbo:Mb3027c.
PATRIC	18008394. VBIMycBov88188_3327.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0440.
HOGENOM	HOG000046747.
KO	K01653.
OMA	RMTIVVN.
ProtClustDB	PRK11895.
Enzyme and pathway databases
UniPathway	UPA00047; UER00055. UPA00049; UER00059.
Family and domain databases
InterPro	IPR004789. Acetalactate_synth_ssu. IPR019455. Acetolactate_synth_ssu_C. [Graphical view]
Pfam	PF10369. ALS_ss_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00119. acolac_sm. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ILVH_MYCBO

Accession

Primary (citable) accession number: P65162
Secondary accession number(s): O53249

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program