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P65154 (ILVD_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxy-acid dehydratase
Short name=DAD
EC=4.2.1.9
Gene names
Name:ilvD
Ordered Locus Names:Rv0189c, MT0199
ORF Names:MTCI28.28c
OrganismMycobacterium tuberculosis
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length575 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O. HAMAP MF_00012

Cofactor

Binds 1 4Fe-4S cluster Potential.

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4. HAMAP MF_00012

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4. HAMAP MF_00012

Sequence similarities

Belongs to the IlvD/Edd family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 575575Dihydroxy-acid dehydratase HAMAP MF_00012
PRO_0000103481

Sites

Metal binding1371Iron-sulfur (4Fe-4S) Potential
Metal binding2141Iron-sulfur (4Fe-4S) Potential

Sequences

Sequence LengthMass (Da)Tools
P65154 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 6ECC279BF886A0F1

FASTA57559,352
        10         20         30         40         50         60 
MPQTTDEAAS VSTVADIKPR SRDVTDGLEK AAARGMLRAV GMDDEDFAKP QIGVASSWNE 

        70         80         90        100        110        120 
ITPCNLSLDR LANAVKEGVF SAGGYPLEFG TISVSDGISM GHEGMHFSLV SREVIADSVE 

       130        140        150        160        170        180 
VVMQAERLDG SVLLAGCDKS LPGMLMAAAR LDLAAVFLYA GSILPGRAKL SDGSERDVTI 

       190        200        210        220        230        240 
IDAFEAVGAC SRGLMSRADV DAIERAICPG EGACGGMYTA NTMASAAEAL GMSLPGSAAP 

       250        260        270        280        290        300 
PATDRRRDGF ARRSGQAVVE LLRRGITARD ILTKEAFENA IAVVMAFGGS TNAVLHLLAI 

       310        320        330        340        350        360 
AHEANVALSL QDFSRIGSGV PHLADVKPFG RHVMSDVDHI GGVPVVMKAL LDAGLLHGDC 

       370        380        390        400        410        420 
LTVTGHTMAE NLAAITPPDP DGKVLRALAN PIHPSGGITI LHGSLAPEGA VVKTAGFDSD 

       430        440        450        460        470        480 
VFEGTARVFD GERAALDALE DGTITVGDAV VIRYEGPKGG PGMREMLAIT GAIKGAGLGK 

       490        500        510        520        530        540 
DVLLLTDGRF SGGTTGLCVG HIAPEAVDGG PIALLRNGDR IRLDVAGRVL DVLADPAEFA 

       550        560        570 
SRQQDFSPPP PRYTTGVLSK YVKLVSSAAV GAVCG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842572 Genomic DNA. Translation: CAB09740.1.
AE000516 Genomic DNA. Translation: AAK44419.1.
PIRH70906.
RefSeqNP_214703.1. NC_000962.2.
NP_334605.1. NC_002755.2.

3D structure databases

ProteinModelPortalP65154.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBMYCT00000002913; EBMYCP00000002913; EBMYCG00000002911.
EBMYCT00000070841; EBMYCP00000068900; EBMYCG00000070836.
GeneID886774.
923084.
GenomeReviewsGene locus MT0199 in contig AE000516_GR.
Gene locus Rv0189c in contig AL123456_GR.
KEGGmtc:MT0199.
mtu:Rv0189c.
PATRIC18122163. VBIMycTub22151_0216.
TIGRMT0199.

Organism-specific databases

TubercuListRv0189c.

Phylogenomic databases

GeneTreeEBGT00050000016366.
HOGENOMHBG671001.
OMANMPGAMI.
PhylomeDBP65154.
ProtClustDBPRK00911.

Family and domain databases

HAMAPMF_00012. IlvD.
[Tree]
InterProIPR015928. Aconitase/3IPM_dehydase_swvl.
IPR004404. DihydroxyA_deHydtase.
IPR000581. DiOHA_6PGluconate_deHydtase.
IPR020558. DiOHA_6PGluconate_deHydtase_CS.
[Graphical view]
KOK01687.
PANTHERPTHR21000. ILVD_EDD_family. 1 hit.
PfamPF00920. ILVD_EDD. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00110. IlvD. 1 hit.
PROSITEPS00886. ILVD_EDD_1. 1 hit.
PS00887. ILVD_EDD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameILVD_MYCTU
AccessionPrimary (citable) accession number: P65154
Secondary accession number(s): O07433
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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