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Protein

Translation initiation factor IF-1

Gene

infA

Organism
Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor, RNA-binding, rRNA-binding
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciPPUT160488:G1G01-4274-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-1UniRule annotation
Gene namesi
Name:infAUniRule annotation
Ordered Locus Names:PP_4007
OrganismiPseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
Taxonomic identifieri160488 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000000556 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000958451 – 72Translation initiation factor IF-1Add BLAST72

Proteomic databases

PRIDEiP65117

Interactioni

Subunit structurei

Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.UniRule annotation

Protein-protein interaction databases

STRINGi160488.PP_4007

Structurei

3D structure databases

ProteinModelPortaliP65117
SMRiP65117
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 72S1-likeUniRule annotationAdd BLAST72

Sequence similaritiesi

Belongs to the IF-1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105K9U Bacteria
COG0361 LUCA
HOGENOMiHOG000221323
KOiK02518
OMAiAHVSGKM

Family and domain databases

CDDicd04451 S1_IF1, 1 hit
HAMAPiMF_00075 IF_1, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR006196 RNA-binding_domain_S1_IF1
IPR022967 S1_dom
IPR004368 TIF_IF1
PANTHERiPTHR33370 PTHR33370, 1 hit
PfamiView protein in Pfam
PF01176 eIF-1a, 1 hit
SMARTiView protein in SMART
SM00316 S1, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00008 infA, 1 hit
PROSITEiView protein in PROSITE
PS50832 S1_IF1_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

P65117-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKEDSFEME GTVVDTLPNT MFRVELENGH VVTAHISGKM RKNYIRILTG
60 70
DKVRVELTPY DLSKGRITYR AR
Length:72
Mass (Da):8,303
Last modified:October 11, 2004 - v1
Checksum:i97E5EEFD8F3886DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE015451 Genomic DNA Translation: AAN69601.1
RefSeqiNP_746137.1, NC_002947.4
WP_002553999.1, NC_002947.4

Genome annotation databases

EnsemblBacteriaiAAN69601; AAN69601; PP_4007
GeneIDi1046554
5108232
KEGGippu:PP_4007
PATRICifig|160488.4.peg.4263

Similar proteinsi

Entry informationi

Entry nameiIF1_PSEPK
AccessioniPrimary (citable) accession number: P65117
Secondary accession number(s): Q9I0L9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health