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Protein

Isopentenyl-diphosphate delta-isomerase

Gene

fni

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).UniRule annotation

Catalytic activityi

Isopentenyl diphosphate = dimethylallyl diphosphate.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • FMNUniRule annotation
  • NADPHUniRule annotation
  • Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951FMN; via amide nitrogenUniRule annotation
Binding sitei124 – 1241FMNUniRule annotation
Binding sitei154 – 1541SubstrateUniRule annotation
Metal bindingi155 – 1551MagnesiumUniRule annotation
Binding sitei186 – 1861FMNUniRule annotation
Binding sitei211 – 2111FMNUniRule annotation
Binding sitei216 – 2161FMN; via amide nitrogenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 673FMNUniRule annotation
Nucleotide bindingi262 – 2643FMNUniRule annotation
Nucleotide bindingi283 – 2842FMNUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

Flavoprotein, FMN, Magnesium, Metal-binding, NADP

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2414-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isopentenyl-diphosphate delta-isomeraseUniRule annotation (EC:5.3.3.2UniRule annotation)
Short name:
IPP isomeraseUniRule annotation
Alternative name(s):
Isopentenyl diphosphate:dimethylallyl diphosphate isomeraseUniRule annotation
Isopentenyl pyrophosphate isomeraseUniRule annotation
Type 2 isopentenyl diphosphate isomeraseUniRule annotation
Short name:
IDI-2UniRule annotation
Gene namesi
Name:fniUniRule annotation
Ordered Locus Names:SAV2346
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Isopentenyl-diphosphate delta-isomerasePRO_0000134421Add
BLAST

Proteomic databases

PaxDbiP65102.

Interactioni

Subunit structurei

Homooctamer. Dimer of tetramers.UniRule annotation

Protein-protein interaction databases

STRINGi158878.SAV2346.

Structurei

3D structure databases

ProteinModelPortaliP65102.
SMRiP65102. Positions 25-345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 102Substrate bindingUniRule annotation
Regioni95 – 973Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the IPP isomerase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106UJV. Bacteria.
COG1304. LUCA.
HOGENOMiHOG000072127.
KOiK01823.
OMAiGSQRVML.
OrthoDBiEOG62C9GJ.
PhylomeDBiP65102.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00354. Idi_2.
InterProiIPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR011179. IPdP_isomerase.
[Graphical view]
PANTHERiPTHR10578:SF3. PTHR10578:SF3. 2 hits.
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMsiTIGR02151. IPP_isom_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P65102-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDFQREQRK NEHVEIAMAQ SDAMHSDFDK MRFVHHSIPS INVNDIDLTS
60 70 80 90 100
QTPDLTMAYP IYINAMTGGS EWTKNINEKL AVVARETRLA MAVGSTHAAL
110 120 130 140 150
RNPRMAETFT IARKMNPEGM IFSNVGADVP VEKALEAVEL LEAQALQIHV
160 170 180 190 200
NSPQELVMPE GNREFVTWLD NIASIVSRVS VPVIIKEVGF GMSKELMHDL
210 220 230 240 250
QQIGVKYVDV SGKGGTNFVD IENERRANKD MDYLSSWGQS TVESLLETTA
260 270 280 290 300
YQSEISVFAS GGLRTPLDAI KSLALGAKAT GMSRPFLNQV ENNGIAHTVA
310 320 330 340
YVESFIEHMK SIMTMLDAKN IDDLTQKQIV FSPEIMSWIE QRSLNIHRG
Length:349
Mass (Da):38,874
Last modified:October 11, 2004 - v1
Checksum:i9A13C4DA4188AF00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58508.1.
RefSeqiWP_001279375.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB58508; BAB58508; SAV2346.
KEGGisav:SAV2346.
PATRICi19565606. VBIStaAur52173_2429.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA. Translation: BAB58508.1.
RefSeqiWP_001279375.1. NC_002758.2.

3D structure databases

ProteinModelPortaliP65102.
SMRiP65102. Positions 25-345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi158878.SAV2346.

Proteomic databases

PaxDbiP65102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB58508; BAB58508; SAV2346.
KEGGisav:SAV2346.
PATRICi19565606. VBIStaAur52173_2429.

Phylogenomic databases

eggNOGiENOG4106UJV. Bacteria.
COG1304. LUCA.
HOGENOMiHOG000072127.
KOiK01823.
OMAiGSQRVML.
OrthoDBiEOG62C9GJ.
PhylomeDBiP65102.

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-2414-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00354. Idi_2.
InterProiIPR013785. Aldolase_TIM.
IPR000262. FMN-dep_DH.
IPR011179. IPdP_isomerase.
[Graphical view]
PANTHERiPTHR10578:SF3. PTHR10578:SF3. 2 hits.
PfamiPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF003314. IPP_isomerase. 1 hit.
TIGRFAMsiTIGR02151. IPP_isom_2. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiIDI2_STAAM
AccessioniPrimary (citable) accession number: P65102
Secondary accession number(s): Q99RS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 16, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.