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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94NADPBy similarity1
Binding sitei103SubstrateBy similarity1
Binding sitei105SubstrateBy similarity1
Binding sitei109SubstrateBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei143SubstrateBy similarity1
Sitei150Critical for catalysisBy similarity1
Sitei220Critical for catalysisBy similarity1
Metal bindingi310Magnesium or manganeseBy similarity1
Binding sitei357NADP; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei396NADPBy similarity1
Binding sitei400NADPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi344 – 350NADPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle
LigandMagnesium, Manganese, Metal-binding, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Synonyms:citC
Ordered Locus Names:SAV1694
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000002481 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835601 – 422Isocitrate dehydrogenase [NADP]Add BLAST422

Proteomic databases

PaxDbiP65099

2D gel databases

World-2DPAGE0002:P65099

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi158878.SAV1694

Structurei

3D structure databases

ProteinModelPortaliP65099
SMRiP65099
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4108HMX Bacteria
COG0538 LUCA
HOGENOMiHOG000021113
KOiK00031
OMAiFQQIQTR
PhylomeDBiP65099

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004439 Isocitrate_DH_NADP_dimer_prok
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR43504 PTHR43504, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00183 prok_nadp_idh, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

P65099-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAEKITQGT EGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN
60 70 80 90 100
GEKRIEWKEV LAGQKAFDTT GEWLPQETLD TIKEYLIAVK GPLTTPIGGG
110 120 130 140 150
IRSLNVALRQ ELDLFTCLRP VRWFKGVPSP VKRPQDVDMV IFRENTEDIY
160 170 180 190 200
AGIEFKEGTT EVKKVIDFLQ NEMGATNIRF PETSGIGIKP VSKEGTERLV
210 220 230 240 250
RAAIQYAIDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAL SEFGDQVFTW
260 270 280 290 300
QQYDEIVENE GRDAANAAQE KAEKEGKIII KDSIADIFLQ QILTRPAEHD
310 320 330 340 350
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY
360 370 380 390 400
AGLNKVNPSS VILSSVLMLE HLGWQEAADK ITDSIEDTIA SKVVTYDFAR
410 420
LMDGAEEVST SAFADELIKN LK
Length:422
Mass (Da):46,423
Last modified:October 11, 2004 - v1
Checksum:i50AA94DF122F0DB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000017 Genomic DNA Translation: BAB57856.1
RefSeqiWP_000123165.1, NC_002758.2

Genome annotation databases

EnsemblBacteriaiBAB57856; BAB57856; SAV1694
KEGGisav:SAV1694

Similar proteinsi

Entry informationi

Entry nameiIDH_STAAM
AccessioniPrimary (citable) accession number: P65099
Secondary accession number(s): Q99TG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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