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P65099

- IDH_STAAM

UniProt

P65099 - IDH_STAAM

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Protein
Isocitrate dehydrogenase [NADP]
Gene
icd, citC, SAV1694
Organism
Staphylococcus aureus (strain Mu50 / ATCC 700699)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941NADP By similarity
Binding sitei103 – 1031Substrate By similarity
Binding sitei105 – 1051Substrate By similarity
Binding sitei109 – 1091Substrate By similarity
Binding sitei119 – 1191Substrate By similarity
Binding sitei143 – 1431Substrate By similarity
Sitei150 – 1501Critical for catalysis By similarity
Sitei220 – 2201Critical for catalysis By similarity
Metal bindingi310 – 3101Magnesium or manganese By similarity
Binding sitei357 – 3571NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei396 – 3961NADP By similarity
Binding sitei400 – 4001NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi344 – 3507NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciSAUR158878:GJJ5-1710-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Synonyms:citC
Ordered Locus Names:SAV1694
OrganismiStaphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic identifieri158878 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000002481: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Isocitrate dehydrogenase [NADP]
PRO_0000083560Add
BLAST

Proteomic databases

PRIDEiP65099.

2D gel databases

World-2DPAGE0002:P65099.

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi158878.SAV1694.

Structurei

3D structure databases

ProteinModelPortaliP65099.
SMRiP65099. Positions 3-421.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.
PhylomeDBiP65099.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P65099-1 [UniParc]FASTAAdd to Basket

« Hide

MTAEKITQGT EGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN    50
GEKRIEWKEV LAGQKAFDTT GEWLPQETLD TIKEYLIAVK GPLTTPIGGG 100
IRSLNVALRQ ELDLFTCLRP VRWFKGVPSP VKRPQDVDMV IFRENTEDIY 150
AGIEFKEGTT EVKKVIDFLQ NEMGATNIRF PETSGIGIKP VSKEGTERLV 200
RAAIQYAIDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAL SEFGDQVFTW 250
QQYDEIVENE GRDAANAAQE KAEKEGKIII KDSIADIFLQ QILTRPAEHD 300
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY 350
AGLNKVNPSS VILSSVLMLE HLGWQEAADK ITDSIEDTIA SKVVTYDFAR 400
LMDGAEEVST SAFADELIKN LK 422
Length:422
Mass (Da):46,423
Last modified:October 11, 2004 - v1
Checksum:i50AA94DF122F0DB7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB57856.1.
RefSeqiNP_372218.1. NC_002758.2.

Genome annotation databases

EnsemblBacteriaiBAB57856; BAB57856; SAV1694.
GeneIDi1121669.
KEGGisav:SAV1694.
PATRICi19564140. VBIStaAur52173_1748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000017 Genomic DNA. Translation: BAB57856.1 .
RefSeqi NP_372218.1. NC_002758.2.

3D structure databases

ProteinModelPortali P65099.
SMRi P65099. Positions 3-421.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 158878.SAV1694.

2D gel databases

World-2DPAGE 0002:P65099.

Proteomic databases

PRIDEi P65099.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB57856 ; BAB57856 ; SAV1694 .
GeneIDi 1121669.
KEGGi sav:SAV1694.
PATRICi 19564140. VBIStaAur52173_1748.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.
PhylomeDBi P65099.

Enzyme and pathway databases

BioCyci SAUR158878:GJJ5-1710-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Mu50 / ATCC 700699.

Entry informationi

Entry nameiIDH_STAAM
AccessioniPrimary (citable) accession number: P65099
Secondary accession number(s): Q99TG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: July 9, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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