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Reviewed, UniProtKB/Swiss-Prot P65099 (IDH_STAAM)

Last modified November 4, 2008. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Isocitrate dehydrogenase [NADP]
      Short name=IDH
    EC=1.1.1.42
Alternative name(s):
    Oxalosuccinate decarboxylase
    NADP(+)-specific ICDH
    IDP
Gene names
Name: icd
Synonyms: citC
Ordered Locus Names: SAV1694
OrganismStaphylococcus aureus (strain Mu50 / ATCC 700699) [Complete proteome] [HAMAP]
Taxonomic identifier158878 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

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Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

Oxalosuccinate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

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Ontologies

Keywords

   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   LigandMagnesium
Manganese
Metal-binding
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

manganese ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Isocitrate dehydrogenase [NADP]
PRO_0000083560

Regions

Nucleotide binding344 – 3507NADP By similarity

Sites

Metal binding3101Magnesium or manganese By similarity
Binding site941NADP By similarity
Binding site1031Substrate By similarity
Binding site1051Substrate By similarity
Binding site1091Substrate By similarity
Binding site1191Substrate By similarity
Binding site1431Substrate By similarity
Binding site3571NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding site3961NADP By similarity
Binding site4001NADP By similarity
Site1501Critical for catalysis By similarity
Site2201Critical for catalysis By similarity

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Sequences

Sequence LengthMass (Da)Tools
P65099-1 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 50AA94DF122F0DB7

FASTA42246,423
        10         20         30         40         50         60 
MTAEKITQGT EGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN GEKRIEWKEV 

        70         80         90        100        110        120 
LAGQKAFDTT GEWLPQETLD TIKEYLIAVK GPLTTPIGGG IRSLNVALRQ ELDLFTCLRP 

       130        140        150        160        170        180 
VRWFKGVPSP VKRPQDVDMV IFRENTEDIY AGIEFKEGTT EVKKVIDFLQ NEMGATNIRF 

       190        200        210        220        230        240 
PETSGIGIKP VSKEGTERLV RAAIQYAIDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAL 

       250        260        270        280        290        300 
SEFGDQVFTW QQYDEIVENE GRDAANAAQE KAEKEGKIII KDSIADIFLQ QILTRPAEHD 

       310        320        330        340        350        360 
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY AGLNKVNPSS 

       370        380        390        400        410        420 
VILSSVLMLE HLGWQEAADK ITDSIEDTIA SKVVTYDFAR LMDGAEEVST SAFADELIKN 


LK

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Cross-references

Sequence databases

BA000017 Genomic DNA. Translation: BAB57856.1.
RefSeqNP_372218.1.

3D structure databases

HSSPHSSP built from PDB template 1HQS based on UniProtKB P39126.
SMRP65099. Positions 3-421.
ModBaseSearch...

2-D gel databases

World-2DPAGE0002:P65099.

Genome annotation databases

GeneID1121669.
GenomeReviewsGene locus SAV1694 in contig BA000017_GR.
KEGGsav:SAV1694.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMP65099.

Enzyme and pathway databases

BioCycSAUR158878:SAV1694-MON.

Family and domain databases

InterProIPR004439. IsoCit_DHase_NADP_prok.
IPR001804. IsoCit_IM_DHase.
[Graphical view]
Gene3DG3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHERPTHR11835. IDH_IMDH_dimeric. 1 hit.
PTHR11835:SF1. NADP_IDH_prok. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

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Entry information

Entry nameIDH_STAAM
AccessionPrimary (citable) accession number: P65099
Secondary accession number(s): Q99TG8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 4, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents