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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg2+ or Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80SubstrateBy similarity1
Binding sitei85NADPBy similarity1
Binding sitei112SubstrateBy similarity1
Binding sitei135SubstrateBy similarity1
Sitei142Critical for catalysisBy similarity1
Sitei215Critical for catalysisBy similarity1
Metal bindingi255Magnesium or manganeseBy similarity1
Binding sitei263NADPBy similarity1
Metal bindingi278Magnesium or manganeseBy similarity1
Binding sitei331NADP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 80NADPBy similarity3
Nucleotide bindingi313 – 318NADPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle
LigandMagnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-3540-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Ordered Locus Names:BQ2027_MB3371C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000835541 – 409Isocitrate dehydrogenase [NADP]Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP65098

Structurei

3D structure databases

ProteinModelPortaliP65098
SMRiP65098
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 103Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858
OMAiAMGMYNQ

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

P65098-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNAPKIKVS GPVVELDGDE MTRVIWKLIK DMLILPYLDI RLDYYDLGIE
60 70 80 90 100
HRDATDDQVT IDAAYAIKKH GVGVKCATIT PDEARVEEFN LKKMWLSPNG
110 120 130 140 150
TIRNILGGTI FREPIVISNV PRLVPGWTKP IVIGRHAFGD QYRATNFKVD
160 170 180 190 200
QPGTVTLTFT PADGSAPIVH EMVSIPEDGG VVLGMYNFKE SIRDFARASF
210 220 230 240 250
SYGLNAKWPV YLSTKNTILK AYDGMFKDEF ERVYEEEFKA QFEAAGLTYE
260 270 280 290 300
HRLIDDMVAA CLKWEGGYVW ACKNYDGDVQ SDTVAQGYGS LGLMTSVLMT
310 320 330 340 350
ADGKTVEAEA AHGTVTRHYR QYQAGKPTST NPIASIFAWT RGLQHRGKLD
360 370 380 390 400
GTPEVIDFAH KLESVVIATV ESGKMTKDLA ILIGPEQDWL NSEEFLDAIA

DNLEKELAN
Length:409
Mass (Da):45,514
Last modified:October 11, 2004 - v1
Checksum:iFDBC1989DF42383A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIU02000.1
RefSeqiNP_857016.1, NC_002945.3
WP_003417452.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO44643; CDO44643; Mb3371c
PATRICifig|233413.5.peg.3703

Similar proteinsi

Entry informationi

Entry nameiIDH_MYCBO
AccessioniPrimary (citable) accession number: P65098
Secondary accession number(s): A0A1R3Y3W8, O53389, X2BNC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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