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P65097 (IDH_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP]
Short name=IDH
EC=1.1.1.42
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene names
Name:icd
Ordered Locus Names:Rv3339c, MT3442
ORF Names:MTV016.39c
OrganismMycobacterium tuberculosis [Reference proteome] [HAMAP]
Taxonomic identifier1773 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 409409Isocitrate dehydrogenase [NADP]
PRO_0000083555

Regions

Nucleotide binding78 – 803NADP By similarity
Nucleotide binding313 – 3186NADP By similarity
Region97 – 1037Substrate binding By similarity

Sites

Metal binding2551Magnesium or manganese By similarity
Metal binding2781Magnesium or manganese By similarity
Binding site801Substrate By similarity
Binding site851NADP By similarity
Binding site1121Substrate By similarity
Binding site1351Substrate By similarity
Binding site2631NADP By similarity
Binding site3311NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1421Critical for catalysis By similarity
Site2151Critical for catalysis By similarity

Amino acid modifications

Modified residue971Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P65097 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: FDBC1989DF42383A

FASTA40945,514
        10         20         30         40         50         60 
MSNAPKIKVS GPVVELDGDE MTRVIWKLIK DMLILPYLDI RLDYYDLGIE HRDATDDQVT 

        70         80         90        100        110        120 
IDAAYAIKKH GVGVKCATIT PDEARVEEFN LKKMWLSPNG TIRNILGGTI FREPIVISNV 

       130        140        150        160        170        180 
PRLVPGWTKP IVIGRHAFGD QYRATNFKVD QPGTVTLTFT PADGSAPIVH EMVSIPEDGG 

       190        200        210        220        230        240 
VVLGMYNFKE SIRDFARASF SYGLNAKWPV YLSTKNTILK AYDGMFKDEF ERVYEEEFKA 

       250        260        270        280        290        300 
QFEAAGLTYE HRLIDDMVAA CLKWEGGYVW ACKNYDGDVQ SDTVAQGYGS LGLMTSVLMT 

       310        320        330        340        350        360 
ADGKTVEAEA AHGTVTRHYR QYQAGKPTST NPIASIFAWT RGLQHRGKLD GTPEVIDFAH 

       370        380        390        400 
KLESVVIATV ESGKMTKDLA ILIGPEQDWL NSEEFLDAIA DNLEKELAN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX842582 Genomic DNA. Translation: CAA17111.1.
AE000516 Genomic DNA. Translation: AAK47786.1.
AL123456 Genomic DNA. Translation: CCP46160.1.
PIRB70846.
RefSeqNP_217856.1. NC_000962.3.
NP_337972.1. NC_002755.2.
YP_006516820.1. NC_018143.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HCXX-ray2.18A/B1-409[»]
ProteinModelPortalP65097.
SMRP65097. Positions 6-408.
ModBaseSearch...

Protein-protein interaction databases

STRING83332.Rv3339c.

Proteomic databases

PRIDEP65097.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK47786; AAK47786; MT3442.
GeneID13318166.
888013.
926429.
KEGGmtc:MT3442.
mtu:Rv3339c.
mtv:RVBD_3339c.
PATRIC18129316. VBIMycTub22151_3754.

Organism-specific databases

TubercuListRv3339c.

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-11946.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIDH_MYCTU
AccessionPrimary (citable) accession number: P65097
Secondary accession number(s): L0TFB7, O53389
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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