ID   COX4_MYCBO              Reviewed;         139 AA.
AC   P64948; A0A1R3Y0J8; Q10406; X2BKD3;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=Probable cytochrome c oxidase polypeptide 4;
DE            EC=7.1.1.9;
DE   AltName: Full=Cytochrome aa3 subunit 4;
DE   AltName: Full=Cytochrome c oxidase polypeptide IV;
GN   Name=ctaF; OrderedLocusNames=BQ2027_MB2222C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: Part of cytochrome c oxidase, its function is unknown.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-
CC         [cytochrome c] + 4 H(+)(out) + 2 H2O; Xref=Rhea:RHEA:11436,
CC         Rhea:RHEA-COMP:10350, Rhea:RHEA-COMP:14399, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:29033,
CC         ChEBI:CHEBI:29034; EC=7.1.1.9;
CC   -!- SUBUNIT: Associates with subunits I, II and III to form cytochrome c
CC       oxidase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome c oxidase bacterial subunit CtaF
CC       family. {ECO:0000305}.
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DR   EMBL; LT708304; SIU00830.1; -; Genomic_DNA.
DR   RefSeq; NP_855871.1; NC_002945.3.
DR   RefSeq; WP_003411408.1; NC_002945.4.
DR   AlphaFoldDB; P64948; -.
DR   SMR; P64948; -.
DR   GeneID; 45426175; -.
DR   PATRIC; fig|233413.5.peg.2438; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR021050; Cyt_c_oxidase_su4_actinobac.
DR   Pfam; PF12270; Cyt_c_ox_IV; 1.
DR   PIRSF; PIRSF017385; CtaF; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Translocase; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..139
FT                   /note="Probable cytochrome c oxidase polypeptide 4"
FT                   /id="PRO_0000220016"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   139 AA;  14865 MW;  EE95E636B2179A6D CRC64;
     MHIEARLFEF VAAFFVVTAV LYGVLTSMFA TGGVEWAGTT ALALTGGMAL IVATFFRFVA
     RRLDSRPEDY EGAEISDGAG ELGFFSPHSW WPIMVALSGS VAAVGIALWL PWLIAAGVAF
     ILASAAGLVF EYYVGPEKH
//