P64948 (COX4_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cytochrome c oxidase polypeptide 4
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 4
Cytochrome c oxidase polypeptide IV

Gene names

Name:	ctaF
Ordered Locus Names:	Mb2222c

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]

Taxonomic identifier

233413 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium bovis

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of cytochrome c oxidase, its function is unknown By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subunit structure	Associates with subunits I, II and III to form cytochrome c oxidase By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase bacterial subunit CtaF family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 139	139	Probable cytochrome c oxidase polypeptide 4		PRO_0000220016
Regions
	Transmembrane	10 – 30	21	Helical; Potential
	Transmembrane	36 – 56	21	Helical; Potential
	Transmembrane	78 – 98	21	Helical; Potential
	Transmembrane	101 – 121	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P64948 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: EE95E636B2179A6D	FASTA	139	14,865
	10 20 30 40 50 60 MHIEARLFEF VAAFFVVTAV LYGVLTSMFA TGGVEWAGTT ALALTGGMAL IVATFFRFVA 70 80 90 100 110 120 RRLDSRPEDY EGAEISDGAG ELGFFSPHSW WPIMVALSGS VAAVGIALWL PWLIAAGVAF 130 ILASAAGLVF EYYVGPEKH

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248341 Genomic DNA. Translation: CAD97075.1.
RefSeq	NP_855871.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P64948.
ModBase	Search...
Protein-protein interaction databases
STRING	233413.Mb2222c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD97075; CAD97075; Mb2222c.
GeneID	1091343.
KEGG	mbo:Mb2222c.
PATRIC	18006584. VBIMycBov88188_2438.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG07397.
HOGENOM	HOG000237887.
OMA	YFRFVAR.
ProtClustDB	CLSK872027.
Family and domain databases
InterPro	IPR021050. Cyt_c_oxidase_su4_actinobac. [Graphical view]
Pfam	PF12270. Cyt_c_ox_IV. 1 hit. [Graphical view]
PIRSF	PIRSF017385. CtaF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COX4_MYCBO

Accession

Primary (citable) accession number: P64948
Secondary accession number(s): Q10406

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program