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Protein

Cob(I)yrinic acid a,c-diamide adenosyltransferase

Gene

BQ2027_MB1347C

Organism
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.
ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide.
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Cob(I)yrinic acid a,c-diamide adenosyltransferase (BQ2027_MB1347C)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. Adenosylcobinamide-GDP ribazoletransferase (cobS)
This subpathway is part of the pathway adenosylcobalamin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes adenosylcobalamin from cob(II)yrinate a,c-diamide, the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28ATPBy similarity1
Binding sitei163ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPBy similarity9
Nucleotide bindingi137 – 142ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCobalamin biosynthesis, Porphyrin biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOV233413:G1GT4-1399-MONOMER
UniPathwayiUPA00148; UER00233

Names & Taxonomyi

Protein namesi
Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase (EC:2.5.1.17)
Alternative name(s):
Cob(I)alamin adenosyltransferase
Gene namesi
Ordered Locus Names:BQ2027_MB1347C
OrganismiMycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
Taxonomic identifieri233413 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000001419 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001037991 – 193Cob(I)yrinic acid a,c-diamide adenosyltransferaseAdd BLAST193

Structurei

3D structure databases

ProteinModelPortaliP64804
SMRiP64804
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000291639
OMAiPRQYLNR

Family and domain databases

Gene3Di1.20.1200.10, 1 hit
InterProiView protein in InterPro
IPR016030 CblAdoTrfase-like
IPR036451 CblAdoTrfase-like_sf
IPR029499 PduO-typ
PANTHERiPTHR12213 PTHR12213, 1 hit
PfamiView protein in Pfam
PF01923 Cob_adeno_trans, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007457 AdoCbl_syn_CblAdoTrfase_PduO_N, 1 hit
SUPFAMiSSF89028 SSF89028, 1 hit
TIGRFAMsiTIGR00636 PduO_Nterm, 1 hit

Sequencei

Sequence statusi: Complete.

P64804-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVHLTRIYT RTGDDGTTGL SDMSRVAKTD ARLVAYADCD EANAAIGAAL
60 70 80 90 100
ALGHPDTQIT DVLRQIQNDL FDAGADLSTP IVENPKHPPL RIAQSYIDRL
110 120 130 140 150
EGWCDAYNAG LPALKSFVLP GGSPLSALLH VARTVVRRAE RSAWAAVDAH
160 170 180 190
PEGVSVLPAK YLNRLSDLLF ILSRVANPDG DVLWRPGGDR TAS
Length:193
Mass (Da):20,694
Last modified:October 11, 2004 - v1
Checksum:i2FB302A9F5A5208B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LT708304 Genomic DNA Translation: SIT99950.1
RefSeqiNP_855001.1, NC_002945.3
WP_003406839.1, NC_002945.4

Genome annotation databases

EnsemblBacteriaiCDO42594; CDO42594; Mb1347c
PATRICifig|233413.5.peg.1476

Entry informationi

Entry nameiPDUO_MYCBO
AccessioniPrimary (citable) accession number: P64804
Secondary accession number(s): A0A1R3XY13, Q10622, X2BHJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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