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P64804 (PDUO_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase

EC=2.5.1.17
Alternative name(s):
Cob(I)alamin adenosyltransferase
Gene names
Ordered Locus Names:Mb1347c
OrganismMycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]
Taxonomic identifier233413 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide.

ATP + cobinamide = triphosphate + adenosylcobinamide.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the Cob(I)alamin adenosyltransferase family.

Ontologies

Keywords
   Biological processCobalamin biosynthesis
Porphyrin biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcobalamin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

porphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cob(I)yrinic acid a,c-diamide adenosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193Cob(I)yrinic acid a,c-diamide adenosyltransferase
PRO_0000103799

Regions

Nucleotide binding10 – 189ATP By similarity
Nucleotide binding137 – 1426ATP By similarity

Sites

Binding site281ATP By similarity
Binding site1631ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P64804 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 2FB302A9F5A5208B

FASTA19320,694
        10         20         30         40         50         60 
MAVHLTRIYT RTGDDGTTGL SDMSRVAKTD ARLVAYADCD EANAAIGAAL ALGHPDTQIT 

        70         80         90        100        110        120 
DVLRQIQNDL FDAGADLSTP IVENPKHPPL RIAQSYIDRL EGWCDAYNAG LPALKSFVLP 

       130        140        150        160        170        180 
GGSPLSALLH VARTVVRRAE RSAWAAVDAH PEGVSVLPAK YLNRLSDLLF ILSRVANPDG 

       190 
DVLWRPGGDR TAS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX248333 Genomic DNA. Translation: CDO42594.1.
RefSeqNP_855001.1. NC_002945.3.

3D structure databases

ProteinModelPortalP64804.
SMRP64804. Positions 29-188.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING233413.Mb1347c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD94208; CAD94208; Mb1347c.
GeneID1090637.
KEGGmbo:Mb1347c.
PATRIC18004649. VBIMycBov88188_1476.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2096.
HOGENOMHOG000291639.
OMADSFTNMK.
OrthoDBEOG6SZ1P1.

Enzyme and pathway databases

UniPathwayUPA00148; UER00233.

Family and domain databases

Gene3D1.20.1200.10. 1 hit.
InterProIPR016030. AdoCbl_synth_CblAdoTrfase-like.
IPR029499. PduO-typ.
[Graphical view]
PfamPF01923. Cob_adeno_trans. 1 hit.
[Graphical view]
ProDomPD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF89028. SSF89028. 1 hit.
TIGRFAMsTIGR00636. PduO_Nterm. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDUO_MYCBO
AccessionPrimary (citable) accession number: P64804
Secondary accession number(s): Q10622, X2BHJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways