P64804 (PDUO_MYCBO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase
EC=2.5.1.17

Alternative name(s):
Cob(I)alamin adenosyltransferase

Gene names

Ordered Locus Names:

Mb1347c

Organism

Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) [Complete proteome] [HAMAP]

Taxonomic identifier

233413 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium bovis

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide. ATP + cobinamide = triphosphate + adenosylcobinamide.
Pathway	Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the Cob(I)alamin adenosyltransferase family.

Ontologies

Keywords
Biological process	Cobalamin biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cob(I)yrinic acid a,c-diamide adenosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	Cob(I)yrinic acid a,c-diamide adenosyltransferase		PRO_0000103799
Regions
	Nucleotide binding	10 – 18	9	ATP By similarity
	Nucleotide binding	137 – 142	6	ATP By similarity
Sites
	Binding site	28	1	ATP By similarity
	Binding site	163	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P64804 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: 2FB302A9F5A5208B	FASTA	193	20,694
	10 20 30 40 50 60 MAVHLTRIYT RTGDDGTTGL SDMSRVAKTD ARLVAYADCD EANAAIGAAL ALGHPDTQIT 70 80 90 100 110 120 DVLRQIQNDL FDAGADLSTP IVENPKHPPL RIAQSYIDRL EGWCDAYNAG LPALKSFVLP 130 140 150 160 170 180 GGSPLSALLH VARTVVRRAE RSAWAAVDAH PEGVSVLPAK YLNRLSDLLF ILSRVANPDG 190 DVLWRPGGDR TAS

References

[1]

"The complete genome sequence of Mycobacterium bovis." Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J. , Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G. Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-935 / AF2122/97.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX248338 Genomic DNA. Translation: CAD94208.1.
RefSeq	NP_855001.1. NC_002945.3.
3D structure databases
ProteinModelPortal	P64804.
SMR	P64804. Positions 29-188.
ModBase	Search...
Protein-protein interaction databases
STRING	233413.Mb1347c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD94208; CAD94208; Mb1347c.
GeneID	1090637.
KEGG	mbo:Mb1347c.
PATRIC	18004649. VBIMycBov88188_1476.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2096.
HOGENOM	HOG000291639.
OMA	MSHLARP.
ProtClustDB	CLSK871923.
Enzyme and pathway databases
UniPathway	UPA00148; UER00233.
Family and domain databases
Gene3D	1.20.1200.10. 1 hit.
InterPro	IPR016030. AdoCbl_synth_CblAdoTrfase-like. [Graphical view]
Pfam	PF01923. Cob_adeno_trans. 1 hit. [Graphical view]
ProDom	PD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF89028. AdoCbl_synth_CblAdoTrfase-like. 1 hit.
TIGRFAMs	TIGR00636. PduO_Nterm. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PDUO_MYCBO

Accession

Primary (citable) accession number: P64804
Secondary accession number(s): Q10622

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program