Cob(I)yrinic acid a,c-diamide adenosyltransferase

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P64803 (PDUO_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 61. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cob(I)yrinic acid a,c-diamide adenosyltransferase
EC=2.5.1.17

Alternative name(s):
Cob(I)alamin adenosyltransferase

Gene names

Ordered Locus Names:	Rv1314c, MT1354
ORF Names:	MTCY373.34c

Organism

Mycobacterium tuberculosis [Reference proteome] [HAMAP]

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + cob(I)yrinic acid a,c-diamide = triphosphate + adenosylcob(III)yrinic acid a,c-diamide. ATP + cobinamide = triphosphate + adenosylcobinamide.
Pathway	Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the Cob(I)alamin adenosyltransferase family.

Ontologies

Keywords
Biological process	Cobalamin biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW cob(I)yrinic acid a,c-diamide adenosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 193

193

Cob(I)yrinic acid a,c-diamide adenosyltransferase

PRO_0000103798

Regions

Nucleotide binding

10 – 18

ATP By similarity

Nucleotide binding

137 – 142

ATP By similarity

Sites

Binding site

ATP By similarity

Binding site

163

ATP By similarity

Secondary structure

193

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P64803 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: 2FB302A9F5A5208B
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FASTA

193

20,694

        10         20         30         40         50         60 
MAVHLTRIYT RTGDDGTTGL SDMSRVAKTD ARLVAYADCD EANAAIGAAL ALGHPDTQIT 

        70         80         90        100        110        120 
DVLRQIQNDL FDAGADLSTP IVENPKHPPL RIAQSYIDRL EGWCDAYNAG LPALKSFVLP 

       130        140        150        160        170        180 
GGSPLSALLH VARTVVRRAE RSAWAAVDAH PEGVSVLPAK YLNRLSDLLF ILSRVANPDG 

       190 
DVLWRPGGDR TAS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. Barrell B.G. Nature 393:537-544(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"Crystal structure of a putative pduO-type ATP:cobalamin adenosyltransferase from Mycobacterium tuberculosis." Mycobacterium tuberculosis structural genomics consortium (TB) Submitted (MAR-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BX842576 Genomic DNA. Translation: CAA97747.1.
AE000516 Genomic DNA. Translation: AAK45616.1.
AL123456 Genomic DNA. Translation: CCP44071.1.

PIR

F70775.

RefSeq

NP_215830.1. NC_000962.3.
NP_335802.1. NC_002755.2.
YP_006514691.1. NC_018143.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2G2D	X-ray	2.00	A	1-193	[»]

ProteinModelPortal

P64803.

SMR

P64803. Positions 29-188.

ModBase

Search...

Protein-protein interaction databases

STRING

83332.Rv1314c.

Proteomic databases

PRIDE

P64803.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAK45616; AAK45616; MT1354.

GeneID

13319896.
886925.
924704.

KEGG

mtc:MT1354.
mtu:Rv1314c.
mtv:RVBD_1314c.

PATRIC

18124742. VBIMycTub22151_1489.

Organism-specific databases

TubercuList

Rv1314c.

Phylogenomic databases

eggNOG

COG2096.

HOGENOM

HOG000291639.

OMA

MSHLARP.

ProtClustDB

CLSK871923.

Enzyme and pathway databases

UniPathway

UPA00148; UER00233.

Family and domain databases

Gene3D

1.20.1200.10. 1 hit.

InterPro

IPR016030. AdoCbl_synth_CblAdoTrfase-like.
[Graphical view]

Pfam

PF01923. Cob_adeno_trans. 1 hit.
[Graphical view]

ProDom

PD007457. AdoCbl_syn_CblAdoTrfase_PduO_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SUPFAM

SSF89028. AdoCbl_synth_CblAdoTrfase-like. 1 hit.

TIGRFAMs

TIGR00636. PduO_Nterm. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

P64803.

Entry information

Entry name

PDUO_MYCTU

Accession

Primary (citable) accession number: P64803
Secondary accession number(s): L0T6A0, Q10622

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh

Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Other

Entry information

Relevant documents