P64681 (Y085_MYCTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized protein Rv0085/MT0092

Gene names

Ordered Locus Names:	Rv0085, MT0092
ORF Names:	MTCY251.03

Organism

Mycobacterium tuberculosis

Taxonomic identifier

1773 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Miscellaneous	Was identified as a high-confidence drug target.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	growth Inferred from mutant phenotype. Source: MTBBASE
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Uncharacterized protein Rv0085/MT0092		PRO_0000103660
Regions
	Transmembrane	6 – 26	21	Helical; Potential
	Transmembrane	33 – 53	21	Helical; Potential
	Transmembrane	59 – 79	21	Helical; Potential
	Transmembrane	103 – 123	21	Helical; Potential
	Transmembrane	126 – 146	21	Helical; Potential
	Transmembrane	157 – 177	21	Helical; Potential
	Transmembrane	179 – 199	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P64681 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: CB76F31A2972FD3C	FASTA	220	23,042
	10 20 30 40 50 60 MSNANFSILV DFAAGGLVLA SVLIVWRRDL RAIVRLLAWQ GAALAAIPLL RGIRDNDRAL 70 80 90 100 110 120 IAVGIAVLAL RALVLPWLLA RAVGAEAAAQ REATPLVNTA SSLLITAGLT LTAFAITQPV 130 140 150 160 170 180 VNLEPGVTIN AVPAAFAVVL IALFVMTTRL HAVSQAAGFL MLDNGIAATA FLLTAGVPLI 190 200 210 220 VELGASLDVL FAVIVIGVLT GRLRRIFGDA DLDKLRELRD

References

[1]	"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence." Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K. , Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G. Nature 393:537-544(1998) [PubMed: 9634230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 25618 / H37Rv.
[2]	"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains." Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R. , Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M. J. Bacteriol. 184:5479-5490(2002) [PubMed: 12218036] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CDC 1551 / Oshkosh.
[3]	"targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis." Raman K., Yeturu K., Chandra N. BMC Syst. Biol. 2:109-109(2008) [PubMed: 19099550] [Abstract] Cited for: IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX842572 Genomic DNA. Translation: CAA98921.1. AE000516 Genomic DNA. Translation: AAK44317.1.
PIR	E70749.
RefSeq	NP_214599.1. NC_000962.2. NP_334503.1. NC_002755.2.
3D structure databases
ProteinModelPortal	P64681.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000000379; EBMYCP00000000379; EBMYCG00000000379. EBMYCT00000070700; EBMYCP00000068759; EBMYCG00000070695.
GeneID	886973. 922882.
GenomeReviews	Gene locus MT0092 in contig AE000516_GR. Gene locus Rv0085 in contig AL123456_GR.
KEGG	mtc:MT0092. mtu:Rv0085.
PATRIC	18121927. VBIMycTub22151_0098.
TIGR	MT0092.
Organism-specific databases
TubercuList	Rv0085.
Phylogenomic databases
GeneTree	EBGT00050000018003.
HOGENOM	HBG569118.
OMA	QVIGYLM.
ProtClustDB	CLSK790250.
Family and domain databases
KO	K12140.
ProtoNet	Search...

Entry information

Entry name

Y085_MYCTU

Accession

Primary (citable) accession number: P64681
Secondary accession number(s): Q10882

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program