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Protein

Probable [Fe-S]-dependent transcriptional repressor

Gene

feoC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as a transcriptional regulator that controls feoABC expression.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Iron-sulfurUniRule annotation1 Publication1
Metal bindingi61Iron-sulfurUniRule annotation1 Publication1
Metal bindingi64Iron-sulfurUniRule annotation1 Publication1
Metal bindingi70Iron-sulfurUniRule annotation1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12933-MONOMER.
ECOL316407:JW3373-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable [Fe-S]-dependent transcriptional repressor1 PublicationUniRule annotation
Gene namesi
Name:feoCUniRule annotation
Synonyms:yhgG
Ordered Locus Names:b3410, JW3373
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12933. feoC.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001695461 – 78Probable [Fe-S]-dependent transcriptional repressorAdd BLAST78

Proteomic databases

PaxDbiP64638.
PRIDEiP64638.

Expressioni

Inductioni

Up-regulated by S-nitrosoglutathione under anaerobic conditions. Repressed by the global regulator Fur.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4263492. 22 interactors.
IntActiP64638. 3 interactors.
STRINGi511145.b3410.

Structurei

Secondary structure

178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 13Combined sources10
Helixi19 – 25Combined sources7
Helixi30 – 43Combined sources14
Beta strandi45 – 49Combined sources5
Beta strandi74 – 77Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XN7NMR-A1-78[»]
ProteinModelPortaliP64638.
SMRiP64638.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP64638.

Family & Domainsi

Sequence similaritiesi

Belongs to the FeoC family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105RJD. Bacteria.
ENOG411247E. LUCA.
HOGENOMiHOG000247605.
KOiK07490.
OMAiHTPQPMI.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01586. FeoC. 1 hit.
InterProiIPR023732. FeoC.
IPR015102. Tscrpt_reg_HTH_FeoC.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09012. FeoC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

P64638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLIQVRDL LALRGRMEAA QISQTLNTPQ PMINAMLQQL ESMGKAVRIQ
60 70
EEPDGCLSGS CKSCPEGKAC LREWWALR
Length:78
Mass (Da):8,660
Last modified:October 11, 2004 - v1
Checksum:i88976DE22CA9024B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58208.1.
U00096 Genomic DNA. Translation: AAC76435.1.
AP009048 Genomic DNA. Translation: BAE77881.1.
PIRiE65136.
RefSeqiNP_417869.1. NC_000913.3.
WP_000157586.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76435; AAC76435; b3410.
BAE77881; BAE77881; BAE77881.
GeneIDi947918.
KEGGiecj:JW3373.
eco:b3410.
PATRICi32122256. VBIEscCol129921_3505.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA58208.1.
U00096 Genomic DNA. Translation: AAC76435.1.
AP009048 Genomic DNA. Translation: BAE77881.1.
PIRiE65136.
RefSeqiNP_417869.1. NC_000913.3.
WP_000157586.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XN7NMR-A1-78[»]
ProteinModelPortaliP64638.
SMRiP64638.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263492. 22 interactors.
IntActiP64638. 3 interactors.
STRINGi511145.b3410.

Proteomic databases

PaxDbiP64638.
PRIDEiP64638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76435; AAC76435; b3410.
BAE77881; BAE77881; BAE77881.
GeneIDi947918.
KEGGiecj:JW3373.
eco:b3410.
PATRICi32122256. VBIEscCol129921_3505.

Organism-specific databases

EchoBASEiEB2769.
EcoGeneiEG12933. feoC.

Phylogenomic databases

eggNOGiENOG4105RJD. Bacteria.
ENOG411247E. LUCA.
HOGENOMiHOG000247605.
KOiK07490.
OMAiHTPQPMI.

Enzyme and pathway databases

BioCyciEcoCyc:EG12933-MONOMER.
ECOL316407:JW3373-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP64638.
PROiP64638.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
HAMAPiMF_01586. FeoC. 1 hit.
InterProiIPR023732. FeoC.
IPR015102. Tscrpt_reg_HTH_FeoC.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF09012. FeoC. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFEOC_ECOLI
AccessioniPrimary (citable) accession number: P64638
Secondary accession number(s): P46845, Q2M775
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.