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Protein

Probable [Fe-S]-dependent transcriptional repressor FeoC

Gene

feoC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as a transcriptional regulator that controls feoABC expression.UniRule annotation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Iron-sulfurUniRule annotation1 Publication1
Metal bindingi61Iron-sulfurUniRule annotation1 Publication1
Metal bindingi64Iron-sulfurUniRule annotation1 Publication1
Metal bindingi70Iron-sulfurUniRule annotation1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandIron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG12933-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable [Fe-S]-dependent transcriptional repressor FeoC1 PublicationUniRule annotation
Alternative name(s):
Fe(2+) iron transport protein CCurated
Gene namesi
Name:feoCUniRule annotation
Synonyms:yhgG
Ordered Locus Names:b3410, JW3373
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12933 feoC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001695461 – 78Probable [Fe-S]-dependent transcriptional repressor FeoCAdd BLAST78

Proteomic databases

PaxDbiP64638
PRIDEiP64638

Expressioni

Inductioni

Up-regulated by S-nitrosoglutathione under anaerobic conditions. Repressed by the global regulator Fur.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4263492, 22 interactors
IntActiP64638, 3 interactors
STRINGi316385.ECDH10B_3585

Structurei

Secondary structure

178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 13Combined sources10
Helixi19 – 25Combined sources7
Helixi30 – 43Combined sources14
Beta strandi45 – 49Combined sources5
Beta strandi74 – 77Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XN7NMR-A1-78[»]
ProteinModelPortaliP64638
SMRiP64638
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP64638

Family & Domainsi

Sequence similaritiesi

Belongs to the FeoC family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105RJD Bacteria
ENOG411247E LUCA
HOGENOMiHOG000247605
KOiK07490
OMAiHTPQPMI

Family and domain databases

Gene3Di1.10.10.10, 1 hit
HAMAPiMF_01586 FeoC, 1 hit
InterProiView protein in InterPro
IPR023732 FeoC
IPR015102 Tscrpt_reg_HTH_FeoC
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF09012 FeoC, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

Sequencei

Sequence statusi: Complete.

P64638-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLIQVRDL LALRGRMEAA QISQTLNTPQ PMINAMLQQL ESMGKAVRIQ
60 70
EEPDGCLSGS CKSCPEGKAC LREWWALR
Length:78
Mass (Da):8,660
Last modified:October 11, 2004 - v1
Checksum:i88976DE22CA9024B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA58208.1
U00096 Genomic DNA Translation: AAC76435.1
AP009048 Genomic DNA Translation: BAE77881.1
PIRiE65136
RefSeqiNP_417869.1, NC_000913.3
WP_000157586.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76435; AAC76435; b3410
BAE77881; BAE77881; BAE77881
GeneIDi947918
KEGGiecj:JW3373
eco:b3410
PATRICifig|1411691.4.peg.3319

Similar proteinsi

Entry informationi

Entry nameiFEOC_ECOLI
AccessioniPrimary (citable) accession number: P64638
Secondary accession number(s): P46845, Q2M775
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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