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Protein

Probable phospholipid ABC transporter-binding protein MlaB

Gene

mlaB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane.1 Publication

GO - Molecular functioni

  • phospholipid transporter activity Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoCyc
  • response to antibiotic Source: EcoCyc
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:G7658-MONOMER.
ECOL316407:JW5535-MONOMER.

Protein family/group databases

TCDBi3.A.1.27.3. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid ABC transporter-binding protein MlaBCurated
Gene namesi
Name:mlaB
Synonyms:yrbB
Ordered Locus Names:b3191, JW5535
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12797. mlaB.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mutation confers sensitivity to SDS-EDTA and leads to accumulation of phospholipid in the outer leaflet of the outer membrane.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797Probable phospholipid ABC transporter-binding protein MlaBPRO_0000169462Add
BLAST

Proteomic databases

PaxDbiP64602.
PRIDEiP64602.

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MlaF), two transmembrane proteins (MlaE), two cytoplasmic solute-binding proteins (MlaB) and a periplamic solute-binding protein (MlaD).1 Publication

Protein-protein interaction databases

BioGridi4260758. 424 interactions.
DIPiDIP-47898N.
IntActiP64602. 3 interactions.
STRINGi511145.b3191.

Structurei

3D structure databases

ProteinModelPortaliP64602.
SMRiP64602. Positions 13-86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 9797STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105UE2. Bacteria.
COG3113. LUCA.
HOGENOMiHOG000287451.
KOiK07122.
OMAiNPLWDAR.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR002645. STAS_dom.
[Graphical view]
PfamiPF13466. STAS_2. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P64602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESLSWMQT GDTLALSGEL DQDVLLPLWE MREEAVKGIT CIDLSRVSRV
60 70 80 90
DTGGLALLLH LIDLAKKQGN NVTLQGVNDK VYTLAKLYNL PADVLPR
Length:97
Mass (Da):10,680
Last modified:October 11, 2004 - v1
Checksum:iBB71D8F0A23D0225
GO

Sequence cautioni

The sequence AAA57992 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57992.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76223.2.
AP009048 Genomic DNA. Translation: BAE77235.1.
RefSeqiNP_417658.4. NC_000913.3.
WP_000004488.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76223; AAC76223; b3191.
BAE77235; BAE77235; BAE77235.
GeneIDi947954.
KEGGiecj:JW5535.
eco:b3191.
PATRICi32121802. VBIEscCol129921_3285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57992.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76223.2.
AP009048 Genomic DNA. Translation: BAE77235.1.
RefSeqiNP_417658.4. NC_000913.3.
WP_000004488.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP64602.
SMRiP64602. Positions 13-86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260758. 424 interactions.
DIPiDIP-47898N.
IntActiP64602. 3 interactions.
STRINGi511145.b3191.

Protein family/group databases

TCDBi3.A.1.27.3. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP64602.
PRIDEiP64602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76223; AAC76223; b3191.
BAE77235; BAE77235; BAE77235.
GeneIDi947954.
KEGGiecj:JW5535.
eco:b3191.
PATRICi32121802. VBIEscCol129921_3285.

Organism-specific databases

EchoBASEiEB2649.
EcoGeneiEG12797. mlaB.

Phylogenomic databases

eggNOGiENOG4105UE2. Bacteria.
COG3113. LUCA.
HOGENOMiHOG000287451.
KOiK07122.
OMAiNPLWDAR.

Enzyme and pathway databases

BioCyciEcoCyc:G7658-MONOMER.
ECOL316407:JW5535-MONOMER.

Miscellaneous databases

PROiP64602.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR002645. STAS_dom.
[Graphical view]
PfamiPF13466. STAS_2. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLAB_ECOLI
AccessioniPrimary (citable) accession number: P64602
Secondary accession number(s): P45389, Q2M921
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.