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Protein

Transcriptional regulator YqjI

Gene

yqjI

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression.1 Publication

Enzyme regulationi

Divalent metals such as nickel and iron have a similar negative effect on YqjI DNA-binding activity.1 Publication

GO - Molecular functioni

  • DNA binding Source: EcoCyc
  • transcription factor activity, sequence-specific DNA binding Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • negative regulation of transcription, DNA-templated Source: EcoCyc
  • positive regulation of transcription, DNA-templated Source: EcoCyc
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7594-MONOMER.
ECOL316407:JW3042-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulator YqjI
Gene namesi
Name:yqjI
Ordered Locus Names:b3071, JW3042
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12954. yqjI.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Disruption leads to a 40-fold increase in yqjH basal expression.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 207207Transcriptional regulator YqjIPRO_0000169438Add
BLAST

Proteomic databases

PaxDbiP64588.

Expressioni

Inductioni

Autorepressed.1 Publication

Interactioni

Subunit structurei

Oligomer (probable predominant form) and monomer.1 Publication

Protein-protein interaction databases

BioGridi4259594. 11 interactions.
DIPiDIP-48127N.
IntActiP64588. 4 interactions.
MINTiMINT-1269480.
STRINGi511145.b3071.

Structurei

3D structure databases

ProteinModelPortaliP64588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105NTW. Bacteria.
COG1695. LUCA.
HOGENOMiHOG000221100.
InParanoidiP64588.
OMAiNASHGYE.
PhylomeDBiP64588.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005149. Tscrpt_reg_PadR_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03551. PadR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.

Sequencei

Sequence statusi: Complete.

P64588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHHHEGCCK HEGQPRHEGC CKGEKSEHEH CGHGHQHEHG QCCGGRHGRG
60 70 80 90 100
GGRRQRFFGH GELRLVILDI LSRDDSHGYE LIKAIENLTQ GNYTPSPGVI
110 120 130 140 150
YPTLDFLQEQ SLITIREEEG GKKQIALTEQ GAQWLEENRE QVEMIEERIK
160 170 180 190 200
ARCVGAALRQ NPQMKRALDN FKAVLDLRVN QSDISDAQIK KIIAVIDRAA

FDITQLD
Length:207
Mass (Da):23,401
Last modified:October 11, 2004 - v1
Checksum:iDD3D108D83E087F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28379 Genomic DNA. Translation: AAA89150.1.
U00096 Genomic DNA. Translation: AAC76106.1.
AP009048 Genomic DNA. Translation: BAE77121.1.
PIRiD65095.
RefSeqiNP_417542.1. NC_000913.3.
WP_000018003.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76106; AAC76106; b3071.
BAE77121; BAE77121; BAE77121.
GeneIDi947584.
KEGGiecj:JW3042.
eco:b3071.
PATRICi32121558. VBIEscCol129921_3165.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28379 Genomic DNA. Translation: AAA89150.1.
U00096 Genomic DNA. Translation: AAC76106.1.
AP009048 Genomic DNA. Translation: BAE77121.1.
PIRiD65095.
RefSeqiNP_417542.1. NC_000913.3.
WP_000018003.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP64588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259594. 11 interactions.
DIPiDIP-48127N.
IntActiP64588. 4 interactions.
MINTiMINT-1269480.
STRINGi511145.b3071.

Proteomic databases

PaxDbiP64588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76106; AAC76106; b3071.
BAE77121; BAE77121; BAE77121.
GeneIDi947584.
KEGGiecj:JW3042.
eco:b3071.
PATRICi32121558. VBIEscCol129921_3165.

Organism-specific databases

EchoBASEiEB2788.
EcoGeneiEG12954. yqjI.

Phylogenomic databases

eggNOGiENOG4105NTW. Bacteria.
COG1695. LUCA.
HOGENOMiHOG000221100.
InParanoidiP64588.
OMAiNASHGYE.
PhylomeDBiP64588.

Enzyme and pathway databases

BioCyciEcoCyc:G7594-MONOMER.
ECOL316407:JW3042-MONOMER.

Miscellaneous databases

PROiP64588.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005149. Tscrpt_reg_PadR_N.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF03551. PadR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiYQJI_ECOLI
AccessioniPrimary (citable) accession number: P64588
Secondary accession number(s): Q2M9D5, Q46872
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.