P64588 (YQJI_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcriptional regulator YqjI

Gene names

Name:	yqjI
Ordered Locus Names:	b3071, JW3042

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Represses the expression of YqjH which is involved in iron homeostasis under excess nickel conditions. Also represses its own expression. Ref.3
Enzyme regulation	Divalent metals such as nickel and iron have a similar negative effect on YqjI DNA-binding activity. Ref.3
Subunit structure	Oligomer (probable predominant form) and monomer. Ref.3
Induction	Autorepressed. Ref.3
Disruption phenotype	Disruption leads to a 40-fold increase in yqjH basal expression. Ref.3

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW response to DNA damage stimulus Inferred from expression pattern PubMed 11967071. Source: EcoliWiki transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Transcriptional regulator YqjI		PRO_0000169438

Sequences

	Sequence		Length	Mass (Da)
	P64588 [UniParc]. Last modified October 11, 2004. Version 1. Checksum: DD3D108D83E087F7	FASTA	207	23,401
	10 20 30 40 50 60 MSHHHEGCCK HEGQPRHEGC CKGEKSEHEH CGHGHQHEHG QCCGGRHGRG GGRRQRFFGH 70 80 90 100 110 120 GELRLVILDI LSRDDSHGYE LIKAIENLTQ GNYTPSPGVI YPTLDFLQEQ SLITIREEEG 130 140 150 160 170 180 GKKQIALTEQ GAQWLEENRE QVEMIEERIK ARCVGAALRQ NPQMKRALDN FKAVLDLRVN 190 200 QSDISDAQIK KIIAVIDRAA FDITQLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[3]	"Fur and the novel regulator YqjI control transcription of the ferric reductase gene yqjH in Escherichia coli." Wang S., Wu Y., Outten F.W. J. Bacteriol. 193:563-574(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION AS A TRANSCRIPTIONAL REGULATOR, DISRUPTION PHENOTYPE, ENZYME REGULATION, SUBUNIT, INDUCTION. Strain: K12 / MG1655 / ATCC 47076.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U28379 Genomic DNA. Translation: AAA89150.1. U00096 Genomic DNA. Translation: AAC76106.1. AP009048 Genomic DNA. Translation: BAE77121.1.
PIR	D65095.
RefSeq	NP_417542.1. NC_000913.2. YP_491262.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P64588.
SMR	P64588. Positions 58-150.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48127N.
IntAct	P64588. 4 interactions.
MINT	MINT-1269480.
STRING	511145.b3071.
Proteomic databases
PaxDb	P64588.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC76106; AAC76106; b3071. BAE77121; BAE77121; BAE77121.
GeneID	12930600. 947584.
KEGG	ecj:Y75_p2996. eco:b3071.
PATRIC	32121558. VBIEscCol129921_3165.
Organism-specific databases
EchoBASE	EB2788.
EcoGene	EG12954. yqjI.
Phylogenomic databases
eggNOG	COG1695.
HOGENOM	HOG000221100.
OMA	NASHGYE.
ProtClustDB	CLSK880568.
Enzyme and pathway databases
BioCyc	EcoCyc:G7594-MONOMER. ECOL316407:JW3042-MONOMER.
Gene expression databases
Genevestigator	P64588.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR005149. Tscrpt_reg_PadR_N. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF03551. PadR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YQJI_ECOLI

Accession

Primary (citable) accession number: P64588
Secondary accession number(s): Q2M9D5, Q46872

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	October 11, 2004
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program