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Protein

Antitoxin CptB

Gene

cptB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Antitoxin component of a toxin-antitoxin (TA) module. When coexpressed with cognate toxin CptA, the antitoxin neutralizes CptA's toxicity. Has been suggested to be a transcriptional regulator.1 Publication

GO - Biological processi

  • protein flavinylation Source: EcoCyc
  • succinate metabolic process Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7510-MONOMER.
ECOL316407:JW2865-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Antitoxin CptB
Gene namesi
Name:cptB
Synonyms:ygfY
Ordered Locus Names:b2897, JW2865
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13075. cptB.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002143941 – 88Antitoxin CptBAdd BLAST88

Proteomic databases

PaxDbiP64559.
PRIDEiP64559.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi4262342. 18 interactors.
IntActiP64559. 6 interactors.
STRINGi511145.b2897.

Structurei

Secondary structure

188
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 12Combined sources7
Helixi18 – 31Combined sources14
Helixi32 – 34Combined sources3
Helixi37 – 47Combined sources11
Helixi51 – 58Combined sources8
Beta strandi61 – 66Combined sources6
Helixi67 – 83Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X6IX-ray1.20A/B1-88[»]
1X6JX-ray2.00A1-88[»]
ProteinModelPortaliP64559.
SMRiP64559.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP64559.

Family & Domainsi

Sequence similaritiesi

Belongs to the CptB antitoxin family.Curated

Phylogenomic databases

eggNOGiENOG4105Y75. Bacteria.
COG2938. LUCA.
HOGENOMiHOG000160701.
InParanoidiP64559.
KOiK09159.
OMAiDLFAWFM.

Family and domain databases

Gene3Di1.10.150.250. 1 hit.
InterProiIPR005631. SDH.
[Graphical view]
PfamiPF03937. Sdh5. 1 hit.
[Graphical view]
SUPFAMiSSF109910. SSF109910. 1 hit.

Sequencei

Sequence statusi: Complete.

P64559-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDINNKARIH WACRRGMREL DISIMPFFEH EYDSLSDDEK RIFIRLLECD
60 70 80
DPDLFNWLMN HGKPADAELE MMVRLIQTRN RERGPVAI
Length:88
Mass (Da):10,547
Last modified:October 11, 2004 - v1
Checksum:iB7047D93220989DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83078.1.
U00096 Genomic DNA. Translation: AAC75935.1.
AP009048 Genomic DNA. Translation: BAE76962.1.
PIRiA65074.
RefSeqiNP_417373.1. NC_000913.3.
WP_000354046.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75935; AAC75935; b2897.
BAE76962; BAE76962; BAE76962.
GeneIDi947382.
KEGGiecj:JW2865.
eco:b2897.
PATRICi32121206. VBIEscCol129921_2991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28375 Genomic DNA. Translation: AAA83078.1.
U00096 Genomic DNA. Translation: AAC75935.1.
AP009048 Genomic DNA. Translation: BAE76962.1.
PIRiA65074.
RefSeqiNP_417373.1. NC_000913.3.
WP_000354046.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X6IX-ray1.20A/B1-88[»]
1X6JX-ray2.00A1-88[»]
ProteinModelPortaliP64559.
SMRiP64559.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262342. 18 interactors.
IntActiP64559. 6 interactors.
STRINGi511145.b2897.

Proteomic databases

PaxDbiP64559.
PRIDEiP64559.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC75935; AAC75935; b2897.
BAE76962; BAE76962; BAE76962.
GeneIDi947382.
KEGGiecj:JW2865.
eco:b2897.
PATRICi32121206. VBIEscCol129921_2991.

Organism-specific databases

EchoBASEiEB2885.
EcoGeneiEG13075. cptB.

Phylogenomic databases

eggNOGiENOG4105Y75. Bacteria.
COG2938. LUCA.
HOGENOMiHOG000160701.
InParanoidiP64559.
KOiK09159.
OMAiDLFAWFM.

Enzyme and pathway databases

BioCyciEcoCyc:G7510-MONOMER.
ECOL316407:JW2865-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP64559.
PROiP64559.

Family and domain databases

Gene3Di1.10.150.250. 1 hit.
InterProiIPR005631. SDH.
[Graphical view]
PfamiPF03937. Sdh5. 1 hit.
[Graphical view]
SUPFAMiSSF109910. SSF109910. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPTB_ECOLI
AccessioniPrimary (citable) accession number: P64559
Secondary accession number(s): Q2M9U4, Q46825
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.