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P64554 (YGCF_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
7-carboxy-7-deazaguanine synthase homolog
Gene names
Name:ygcF
Ordered Locus Names:b2777, JW2748
OrganismEscherichia coli (strain K12)
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Cofactor

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine Potential.

Sequence similarities

Belongs to the radical SAM superfamily.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

rplBP604221EBI-1126335,EBI-543515

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2232237-carboxy-7-deazaguanine synthase homolog
PRO_0000169316

Sites

Metal binding311Iron-sulfur (4Fe-4S-S-AdoMet) Potential
Metal binding351Iron-sulfur (4Fe-4S-S-AdoMet) Potential
Metal binding381Iron-sulfur (4Fe-4S-S-AdoMet) Potential

Sequences

Sequence LengthMass (Da)Tools
P64554 [UniParc].

Last modified October 11, 2004. Version 1.
Checksum: A717AAF18F2A5D70

FASTA22325,030
        10         20         30         40         50         60 
MQYPINEMFQ TLQGEGYFTG VPAIFIRLQG CPVGCAWCDT KHTWEKLEDR EVSLFSILAK 

        70         80         90        100        110        120 
TKESDKWGAA SSEDLLAVIG RQGYTARHVV ITGGEPCIHD LLPLTDLLEK NGFSCQIETS 

       130        140        150        160        170        180 
GTHEVRCTPN TWVTVSPKLN MRGGYEVLSQ ALERANEIKH PVGRVRDIEA LDELLATLTD 

       190        200        210        220 
DKPRVIALQP ISQKDDATRL CIETCIARNW RLSMQTHKYL NIA 

« Hide

References

[1]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U29580 Genomic DNA. Translation: AAA69287.1.
U00096 Genomic DNA. Translation: AAC75819.1.
AP009048 Genomic DNA. Translation: BAE76851.1.
PIRE65059.
RefSeqNP_417257.1. NC_000913.2.

3D structure databases

ProteinModelPortalP64554.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-48192N.
IntActP64554. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000000289; EBESCP00000000289; EBESCG00000000239.
EBESCT00000014985; EBESCP00000014276; EBESCG00000014045.
GeneID947527.
GenomeReviewsGene locus JW2748 in contig AP009048_GR.
Gene locus b2777 in contig U00096_GR.
KEGGecj:JW2748.
eco:b2777.
PATRIC32120968. VBIEscCol129921_2876.

Organism-specific databases

EchoBASEEB2849.
EcoGeneEG13034. ygcF.

Phylogenomic databases

eggNOGCOG0602.
GeneTreeEBGT00050000009993.
HOGENOMHBG507714.
OMATICLQPI.
PhylomeDBP64554.
ProtClustDBCLSK874339.

Enzyme and pathway databases

BioCycEcoCyc:G7443-MONOMER.

Gene expression databases

GenevestigatorP64554.

Family and domain databases

InterProIPR024924. 7-CO-7-deazaguanine_synth-like.
IPR013785. Aldolase_TIM.
IPR007197. rSAM.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK10026.
PfamPF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFPIRSF000370. QueE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameYGCF_ECOLI
AccessionPrimary (citable) accession number: P64554
Secondary accession number(s): P55139, Q2MA55
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families