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Protein

Nickel/cobalt homeostasis protein RcnB

Gene

rcnB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly.1 Publication

GO - Molecular functioni

  • copper ion binding Source: EcoCyc

GO - Biological processi

  • cellular response to DNA damage stimulus Source: EcoliWiki
  • response to cobalt ion Source: EcoCyc
  • response to nickel cation Source: EcoCyc
  • response to peptide Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:G7139-MONOMER.

Protein family/group databases

TCDBi2.A.113.1.1. the nickel/cobalt transporter (nico) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Nickel/cobalt homeostasis protein RcnB
Gene namesi
Name:rcnB
Synonyms:yohN
Ordered Locus Names:b2107, JW5346
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG14072. rcnB.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: EcoCyc
  • outer membrane-bounded periplasmic space Source: EcoCyc

Keywords - Cellular componenti

Periplasm

Pathology & Biotechi

Disruption phenotypei

Mutants show reduced intracellular nickel or cobalt levels.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001387226 – 112Nickel/cobalt homeostasis protein RcnBAdd BLAST87

Proteomic databases

PaxDbiP64534.
PRIDEiP64534.

Expressioni

Inductioni

Repressed by RcnR. Induced by nickel and cobalt.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4260433. 2 interactors.
DIPiDIP-48070N.
IntActiP64534. 5 interactors.
STRINGi316385.ECDH10B_2260.

Structurei

3D structure databases

ProteinModelPortaliP64534.
SMRiP64534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RcnB family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108Z1S. Bacteria.
COG5455. LUCA.
HOGENOMiHOG000122121.

Family and domain databases

InterProiView protein in InterPro
IPR024572. RcnB.
PfamiView protein in Pfam
PF11776. RcnB. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD456999. PD456999. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P64534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIKNKMLLG ALLLVTSAAW AAPATAGSTN TSGISKYELS SFIADFKHFK
60 70 80 90 100
PGDTVPEMYR TDEYNIKQWQ LRNLPAPDAG THWTYMGGAY VLISDTDGKI
110
IKAYDGEIFY HR
Length:112
Mass (Da):12,466
Last modified:October 11, 2004 - v1
Checksum:iC79685089608624F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC75168.2.
AP009048 Genomic DNA. Translation: BAE76587.1.
RefSeqiNP_416610.4. NC_000913.3.
WP_000153067.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC75168; AAC75168; b2107.
BAE76587; BAE76587; BAE76587.
GeneIDi949080.
KEGGiecj:JW5346.
eco:b2107.
PATRICifig|1411691.4.peg.140.

Similar proteinsi

Entry informationi

Entry nameiRCNB_ECOLI
AccessioniPrimary (citable) accession number: P64534
Secondary accession number(s): P76426, Q2MAW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: August 30, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families